Inhibiteurs et Agonistes des Voies PI3K/Akt/mTOR

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 Publications Citing Use of MCE Products Nature. 2020 Apr;580(7803):386-390.
Cell. 2020 Apr 6. pii: S0092-8674(20)30268-3.
Cell. 2020 Mar 5;180(5):941-955.e20.
Nature. 2020 Mar;579(7799):433-437.
Science. 2020 Feb 14;367(6479):806-810.
Cell. 2020 Feb 20;180(4):645-654.e13.
Nature. 2019 Dec;576(7786):274-280.
Cell. 2019 Dec 12;179(7):1483-1498.e22.
Cell. 2019 Dec 12;179(7):1566-1581.e16.
Nature. 2019 Nov;575(7782):375-379.
Nature. 2019 Nov;575(7784):683-687.
Nature. 2019 Oct;574(7777):264-267.
Cell. 2019 Oct 31;179(4):864-879.e19.
Nat Nanotechnol. 2019 Oct;14(10):988-993.
Nat Biotechnol. 2019 Oct;37(10):1209-1216.
Cell. 2019 Aug 22;178(5):1145-1158.e20.
Cell. 2019 Aug 22;178(5):1132-1144.e10.
Nature. 2019 Jul;571(7763):127-131.
Science. 2019 Jul 19;365(6450).
Cell. 2019 Jul 25;178(3):585-599.e15.
Cell. 2019 Jul 11;178(2):330-345.e22.

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 Table of Contents Signaling Pathways
PI3K/Akt/mTOR 1
Epigenetics 1
Autophagy 2
Apoptosis 2
Cell Cycle/DNA Damage 3
Metabolic Enzyme/Protease 4
Protein Tyrosine Kinase/RTK 5
Immunology/Inflammation 6
Stem Cell/Wnt 6
Anti-infection 7
JAK/STAT Signaling 8
MAPK/ERK Pathway 8
GPCR/G Protein 9
Neuronal Signaling 10
Membrane Transporter/Ion Channel 11
Cytoskeleton 12
NF-?B 12
TGF-beta/Smad 13
VD/VDR 13
Antibody-drug Conjugate/ADC Related 14
PROTAC 15

Compound Screening Libraries 16
Virtual Screening 19
Dye Reagents 22

 www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
PI3K/Akt/mTOR
Akt AMPK Cat. No. Product Name Cat. No. Product Name
ATM/ATR DNA-PK HY-10219 Rapamycin (Sirolimus) HY-13003 Torin 1
GSK-3 MELK HY-15244 Alpelisib HY-15186 Ipatasertib (GDC-0068; RG7440)
mTOR PDK-1 HY-19312 3-Methyladenine (3-MA) HY-13522 Fimepinostat (CUDC-907)
PI3K PI4K HY-10182 CHIR-99021 HY-70063 Buparlisib (BKM120)
PIKfyve PTEN HY-10108 LY294002 HY-13002 Torin 2
HY-10358 MK-2206 HY-13417 AICAR
HY-19323 Ceralasertib (AZD6738) HY-101566A BAY-1895344
HY-12513 LY3023414 HY-P0175 740 Y-P
HY-10218 Everolimus (RAD001) HY-10422 AZD-8055
HY-101562 GDC-0077 HY-13026 Idelalisib (CAL-101; GS-1101)
HY-101570 Nedisertib HY-19939S VX-984
HY-15346 Copanlisib HY-10514 BX795
HY-13902 Berzosertib (VE-822; VX-970) HY-15512A OTSSP167
HY-15431 Capivasertib (AZD5363) HY-13074 VO-Ohpic
HY-17471A Metformin HY-12046 PIK-93
Epigenetics
AMPK Cat. No. Product Name Cat. No. Product Name
Aurora Kinase HY-13030 (+)-JQ-1 HY-15149 Romidepsin (FK 228)
DNA Methyltransferase HY-15743 Birabresib (OTX-015; MK-8628) HY-15145 SRT 1720
Epigenetic Reader Domain HY-13803 Tazemetostat (EPZ-6438) HY-12635 SP2509
HDAC HY-13470 GSK126 HY-108696 GNE-781
Histone Acetyltransferase HY-107455 A-485 HY-A0004 Decitabine (5-Aza-2'-deoxycytidine)
Histone Demethylase HY-104048 QC6352 HY-13980 UNC0642
Histone Methyltransferase HY-101563 GSK3326595 HY-15452 Selisistat (EX-527)
JAK HY-15144 Trichostatin A (TSA) HY-111048 Corin
MicroRNA HY-15229 Guadecitabine (SGI-110) HY-13235 I-BET151
PARP HY-13032 Molibresib (I-BET762; GSK525762) HY-100482 CPI-637
PKC HY-103713 Seclidemstat (SP-2577) HY-12186 3-Deazaneplanocin A (DZNep)
Protein Arginine Deiminase HY-13418 Dorsomorphin (Compound C) HY-100514 GSK484
Sirtuin HY-15648B GSK-J4 HY-16425 RG2833
HY-101564 JNJ-64619178 HY-12163 Entinostat (MS-275)
HY-16925 MI-503 HY-10224 Panobinostat (LBH589)
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 MCE
Master of Small Molecules
Autophagy
Autophagy FKBP Cat. No. Product Name Cat. No. Product Name
LRRK2 Mitophagy HY-11109 Resatorvid (TAK-242) HY-10971 Alisertib (MLN8237?
ULK HY-10162 Olaparib (AZD2281) HY-B0015 Paclitaxel (Taxol)
HY-100411 MLi-2 HY-17559 Actinomycin D
HY-70002 Enzalutamide (MDV3100) HY-17394 Cisplatin (CDDP)
HY-B0146 Verteporfin HY-15371 Forskolin (Coleonol)
HY-13756 Tacrolimus (FK506; Fujimycin) HY-17371 Oxaliplatin
HY-13992 AP20187 HY-13636 Fulvestrant (ICI 182780)
HY-13259 MG-132 HY-12481 SAR405
HY-19312 3-Methyladenine (3-MA) HY-100006A MRT68921
HY-13251 Silvestrol HY-16966 SBI-0206965
HY-12320 Cycloheximide (Actidione; CHX) HY-13018 MRT67307
HY-10108 LY294002 HY-100941 CCCP
HY-15142 Doxorubicin HY-16592 Brefeldin A (BFA)
HY-100558 Bafilomycin A1 HY-12990 Spautin-1
HY-50856 Ruxolitinib (INCB18424) HY-10129 Veliparib (ABT-888)
Apoptosis
Apoptosis Bcl-2 Family Cat. No. Product Name Cat. No. Product Name
c-Myc Caspase HY-100741 S63845 HY-100579 Ferrostatin-1
DAPK Ferroptosis HY-10087 Navitoclax (ABT-263) HY-16046 Rimiducid (AP1903)
FKBP IAP HY-13756 Tacrolimus (FK506; Fujimycin) HY-F0003 NADPH
MDM-2/p53 PKD HY-13992 AP20187 (B/B Homodimerizer) HY-101565 AMG-176
RIP Kinase Survivin HY-16658 Z-VAD(OMe)-FMK HY-101297 Z-IETD-FMK
Thymidylate Synthase HY-15763 Erastin HY-18658 Siremadlin (HDM 201)
TNF Receptor HY-13205 Belnacasan (VX-765) HY-19741 A-1331852
HY-15676 Idasanutlin (RG7388) HY-12466 Z-DEVD-FMK
HY-114481 Imidazole ketone erastin (IKE) HY-102080 SAFit2
HY-12296 AMG 232 HY-12726 Liproxstatin-1
HY-50936 Trabectedin (ET-743) HY-12635 SP2509
HY-15531 Venetoclax (ABT-199; GDC-0199) HY-13002 Torin 2
HY-12305 Q-VD-OPh (QVD-OPH? HY-50907 ABT-737
HY-15518 LCL161 HY-16591 Birinapant
HY-10959 RG7112 HY-10396 Emricasan (PF 03491390)
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 www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
Cell Cycle/DNA Damage
Antifolate Cat. No. Product Name Cat. No. Product Name
APC HY-13631A Exatecan HY-16592 Brefeldin A (BFA)
ATM/ATR HY-13442A Eribulin Mesylate HY-12137 Volasertib (BI 6727)
Aurora Kinase HY-10162 Olaparib (AZD2281) HY-16209 Forodesine (BCX-1777)
Casein Kinase HY-10619 Niraparib (MK-4827) HY-101212 CYC065
CDK HY-114177 PF-06873600 HY-103618 THZ531
Checkpoint Kinase (Chk) HY-16737 Elafibranor (GFT505) HY-13624A Epirubicin (4'-Epidoxorubicin)
CRISPR/Cas9 HY-15162 Monomethyl auristatin E (MMAE) HY-50855 Silmitasertib (CX-4945)
Deubiquitinase HY-13251 Silvestrol HY-50935 Troglitazone (CS-045)
DNA Alkylator/Crosslinker HY-12320 Cycloheximide (Actidione; CHX) HY-17371 Oxaliplatin
DNA-PK HY-16297 Abemaciclib (LY2835219) HY-104044 Pamiparib (BGB-290)
DNA/RNA Synthesis HY-10993 Adavosertib (AZD1775; MK-1775) HY-16261 Aldoxorubicin (INNO-206)
Eukaryotic Initiation Factor (eIF) HY-10617 Rucaparib (AG-014699) HY-80013 THZ1
G-quadruplex HY-50767 Palbociclib (PD 0332991) HY-101566A BAY-1895344
Haspin Kinase HY-13316 Mitomycin C (Ametycine) HY-112162 BOS-172722
HDAC HY-19323 Ceralasertib (AZD6738) HY-10129 Veliparib (ABT-888)
HSP HY-103712A Samuraciclib (CT7001) HY-12214A NVP-2
IRE1 HY-112088 AZD4573 HY-13469 Debio 0932 (CUDC-305)
Kinesin HY-16106 Talazoparib (BMN-673) HY-19831 4EGI-1
LIM Kinase (LIMK) HY-17565 Bleomycin HY-13753 Streptozocin (Streptozotocin)
Microtubule/Tubulin HY-112654 GCN2iB HY-B0779 Teprenone (Geranylgeranylacetone)
Mps1 HY-10971 Alisertib (MLN 8237) HY-12871B Atuveciclib (BAY-1143572)
Nucleoside Antimetabolite/Analog HY-12037 Rigosertib (ON-01910) HY-15372 GW 6471
p97 HY-B0015 Paclitaxel (Taxol) HY-114258 LY3295668 (AK-01)
PAK HY-17559 Actinomycin D HY-90006 5-Fluorouracil (5-FU)
PARP HY-104040 MKC8866 HY-30237 Seliciclib (Roscovitine; CYC202)
PERK HY-19620 Branaplam (LMI070) HY-15725 CDDO-Im (RTA-403)
Polo-like Kinase (PLK) HY-17394 Cisplatin (CDDP) HY-100888 Simurosertib (TAK-931)
PPAR HY-101570 Nedisertib (M3814) HY-18682 Centrinone (LCR-263)
RAD51 HY-10211 Tanespimycin (17-AAG) HY-18072 GSK2606414
ROCK HY-13902 Berzosertib (VE-822; VX-970) HY-17618 Pemafibrate
Sirtuin HY-15777 Ribociclib (LEE011) HY-107986 GNE-6776
SRPK HY-109101 Risdiplam (RG7916; RO7034067) HY-12861 CB-5083
Telomerase HY-18174 Prexasertib (LY2606368) HY-130250 SR-4835
TOPK HY-17364 Temozolomide (TMZ) HY-15147 XAV-939
Topoisomerase HY-10492 Dinaciclib (SCH 727965) HY-13323 CX-5461
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 MCE
Master of Small Molecules
Metabolic Enzyme/Protease
Oxidoreductases: Elastase Cat. No. Product Name Cat. No. Product Name
5 alpha Reductase Factor Xa HY-12248 Telaglenastat HY-10227 Bortezomib
5'-Deiodinase Glucosidase HY-12222 Obeticholic acid HY-N0565B Doxycycline
Aldehyde Dehydrogenase MAGL HY-16901 Firsocostat HY-101560 Linrodostat
Aldose Reductase MMP HY-13756 Tacrolimus HY-14434 Asunaprevir
Cytochrome P450 Neprilysin HY-70062 Pevonedistat HY-15193 EMD638683
Dopamine ?-hydroxylase Phosphatase HY-13259 MG-132 HY-P0025 NIM811
Glutathione Peroxidase Phosphodiesterase (PDE) HY-19312 3-Methyladenine HY-B0764 Bucladesine
HIF/HIF Prolyl-Hydroxylase Phospholipase HY-12219A MSI-1436 HY-100116A Mitoquinone
HMG-CoA Reductase Proteasome HY-15689 Epacadostat HY-13426 Roxadustat
Indoleamine 2,3-Dioxygenase Renin HY-12867 PT-2385 HY-120384 AZD-0284
Isocitrate Dehydrogenase Soluble Epoxide Hydrolase HY-109083 Cilofexor HY-50876 (E)-Daporinad
Lactate Dehydrogenase Thrombin HY-18657 TEPP-46 HY-112929 DT-061
Lipoxygenase Lyases: HY-116009 RMC-4550 HY-108697 PT2399
NADPH Oxidase Carbonic Anhydrase HY-101979A CB-1158 HY-50108 GW 4064
Stearoyl-CoA Desaturase Decarboxylase HY-15424 5-Iodotubercidin HY-17367A Atazanavir
Tryptophan Hydroxylase Enolase HY-107418 Tropifexor HY-17605 Bictegravir
Tyrosinase Ligase: HY-12434 INT-767 HY-13966 2-Deoxy-D-glucose
Xanthine Oxidase Acetyl-CoA Carboxylase HY-15676 Idasanutlin HY-D0937 Methoxy-PMS
Transferases: Isomerase HY-12296 AMG 232 HY-18767 Ivosidenib
COMT Others: HY-100388 SHP099 HY-14771A Imeglimin
Acyltransferase CETP HY-18770B Navoximod HY-10502 Tipifarnib
Carbohydrate transferase Drug Metabolite HY-112645 BAY-2402234 HY-15287A Nelfinavir
E1/E2/E3 Enzyme Endogenous Metabolite HY-101842 ND-646 HY-13469 Debio 0932
Farnesyl Transferase FXR HY-104037 Cintirorgon HY-10912 Fexaramine
Fatty Acid Synthase (FAS) HCV Protease HY-101772 Ziritaxestat HY-14992 Bay 60-7550
Gutathione S-transferase HIV Integrase HY-18950 GSK2795039 HY-B0779 Teprenone
Nampt HIV Protease HY-15371 Forskolin HY-15768 Ilomastat
Pyruvate Kinase LXR HY-16278 Pradigastat HY-104042 Vorasidenib
Hydrolases: Mineralocorticoid Receptor HY-100218A RSL3 HY-15760 Necrostatin-1
Ester hydrolase Mitochondrial Metabolism HY-12270 T-5224 HY-109011 Rosiptor
Adenosine Deaminase RAR/RXR HY-B0763 Ibudilast HY-15148 Tipranavir
Aminopeptidase Reactive Oxygen Species HY-125840 PT2977 HY-13233A Talabostat
ACE ROR HY-100337 WWL70 HY-100742A (R)-GNE-140
Cathepsin Ser/Thr Protease HY-14896 Opicapone HY-100487 TAK-243
Dipeptidyl Peptidase HY-122218 JHU-083 HY-10231 PX-478
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Inhibitors • Agonists • Screening Libraries
Protein Tyrosine Kinase/RTK
Receptor Tyrosine Kinases Cat. No. Product Name Cat. No. Product Name
(RTKs): HY-16749 Pexidartinib (PLX-3397) HY-12050 CP-673451
ALK HY-112301 Pralsetinib (BLU-667) HY-12289 Defactinib (VS-6063)
c-Fms HY-P9907 Trastuzumab HY-18007 ALW-II-41-27
c-Kit HY-10997 Ibrutinib (PCI-32765) HY-100492 Fisogatinib (BLU-554)
c-Met/HGFR HY-114153 PLX5622 HY-101474A Zanubrutinib (BGB-3111)
Discoidin Domain Receptor HY-12768 BLZ945 HY-10181 Dasatinib (BMS-354825)
EGFR HY-109078 Vecabrutinib (SNS-062) HY-13342 Apatinib (YN968D1)
Ephrin Receptor HY-15150 Bemcentinib (R428; BGB324) HY-101916 Heparan
FGFR HY-16961 Sitravatinib (MGCD516) HY-129550 BI-4020
FLT3 HY-15772 Osimertinib (AZD-9291) HY-13024 Rebastinib (DCC-2036)
IGF-1R HY-P9905 Cetuximab (C225) HY-13016 Cabozantinib (XL184)
Insulin Receptor HY-P9906 Bevacizumab HY-10261 Afatinib (BIBW 2992)
PDGFR HY-10374 Semaxinib (SU5416) HY-15730 Poziotinib (HM781-36B)
RET HY-112306 Ripretinib (DCC-2618) HY-50895 Gefitinib (ZD1839)
ROS HY-10981 Lenvatinib (E7080) HY-10191 Linsitinib (OSI-906)
TAM Receptor HY-50904 Nintedanib (BIBF 1120) HY-13001 Quizartinib (AC220)
Trk Receptor HY-112299 TAS6417 HY-12823 BLU9931
VEGFR HY-109099 Pemigatinib (INCB054828) HY-101568 Roblitinib (FGF-401)
HY-18708 Erdafitinib (JNJ-42756493) HY-12866A Larotrectinib (LOXO-101)
HY-17600 Acalabrutinib (ACP-196) HY-112215 ARQ 531
Non-Receptor Tyrosine Kinases HY-P9912 Pertuzumab HY-13223 Crenolanib (CP-868596)
(NRTKs): HY-12432 Gilteritinib (ASP2215) HY-101549 MRX-2843 (UNC2371)
Ack1 HY-18750 AZD3759 HY-128757 Remibrutinib
Bcr-Abl HY-101977 Selitrectinib (LOXO-195) HY-15514A Merestinib (LY2801653)
BMX Kinase HY-100818 Futibatinib (TAS-120) HY-15458 SAR131675
Btk HY-13311 Infigratinib (BGJ-398) HY-15959 Savolitinib (Volitinib; AZD-6094)
FAK HY-114370 Selpercatinib (LOXO-292) HY-11092 BMS-509744
Itk HY-101561 Avapritinib (BLU-285) HY-109086 Edicotinib (JNJ-40346527)
Pyk2 HY-P0035 Insulin (human) HY-103022 Repotrectinib (TPX-0005)
Src HY-100342 Ibrutinib-biotin HY-10200 BMS-754807
Syk HY-104065 Pyrotinib (SHR-1258) HY-12857 Brigatinib (AP-26113)
HY-16069 Tucatinib (Irbinitinib; ONT-380) HY-50878 Crizotinib (PF-02341066)
HY-12215 Lorlatinib (PF-06463922) HY-19834 Fenebrutinib (GDC-0853)
HY-10331 Regorafenib (BAY 73-4506) HY-15764A A 419259 (RK 20449)
HY-100867A TAK-659 HY-101215 Evobrutinib (M2951)
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 MCE
Master of Small Molecules
Immunology/Inflammation
Aryl Hydrocarbon Receptor Cat. No. Product Name Cat. No. Product Name
CCR CD73 HY-12885B ADU-S100 (MIW815) HY-10218 Everolimus (RAD001)
Complement System HY-10037 Quiflapon (MK591) HY-15776 HG-9-91-01
COX CXCR HY-117287 BMS-986165 HY-101147 YKL-05-099
FKBP FLAP HY-11109 Resatorvid (TAK-242) HY-16046 Rimiducid (AP1903)
Galectin IFNAR HY-14882A Cenicriviroc (TAK-652) HY-17589 Chloroquine Phosphate
Interleukin Related HY-13756 Tacrolimus (FK506; Fujimycin) HY-B0579 Cyclosporin A (Cyclosporine)
IRAK MyD88 HY-12815A MCC950 (CP-456773; CRID3) HY-17627 Avacopan (CCX168)
NO Synthase HY-13992 AP20187 HY-108730 Avelumab
NOD-like Receptor (NLR) HY-P9904 Atezolizumab HY-102080 SAFit2
PD-1/PD-L1 PGE Synthase HY-18739 Phorbol 12-myristate 13-acetate HY-109044 Tapinarof (GSK2894512)
Reactive Oxygen Species HY-50937 ST 2825 HY-13740 Resiquimod (R848)
Salt-inducible Kinase (SIK) HY-112921B diABZI STING agonist-1 HY-109104 Telratolimod (MEDI 9197; 3M-052)
SPHK STING HY-10964 Vadimezan (DMXAA; ASA-404) HY-100116A Mitoquinone
Thrombopoietin Receptor HY-13245 PF-4136309 (INCB8761) HY-50674 INCB3344
Toll-like Receptor (TLR) HY-19745 BMS-202 HY-P9903 Nivolumab (BMS-936558)
Stem Cell/Wnt
Casein Kinase ERK Cat. No. Product Name Cat. No. Product Name
Gli GSK-3 HY-B0146 Verteporfin (CL 318952) HY-15147 XAV-939
Hedgehog Hippo (MST) HY-10182 CHIR-99021 (CT99021) HY-12681 CCT251545
JAK Notch HY-10071 Y-27632 HY-13418A Dorsomorphin (Compound C)
Oct3/4 PKA HY-16975 SH-4-54 HY-109049 Adavivint (SM04690)
Porcupine ROCK HY-50846 SCH772984 HY-19369 L-685458
sFRP-1 Smo HY-17545 LGK974 (WNT974) HY-116830 BRD0705
STAT TGF-beta/Smad HY-100526 XMU-MP-1 HY-13257 Thiazovivin
Wnt YAP HY-15307 SLx-2119 (KD-025) HY-11102 RO4929097 (RG-4733)
?-catenin ?-secretase HY-15392 Chroman 1 HY-14176 Compound E
HY-13027 DAPT (GSI-IX) HY-10590 TWS119
HY-14428 ICG-001 HY-16294 LY2090314
HY-50752 LY-411575 HY-14443 XMD8-92
HY-17024 Cyclopamine (11-Deoxojervine) HY-100830 NCB-0846
HY-15185 Nirogacestat (PF-3084014) HY-15659 Wnt-C59 (C59)
HY-13901 GANT 61 (NSC 136476) HY-10046 Plerixafor (AMD 3100)
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Inhibitors • Agonists • Screening Libraries
Anti-infection
Arenavirus Bacterial Cat. No. Product Name Cat. No. Product Name
CMV Enterovirus HY-104077 Remdesivir (GS-5734) HY-17362 Vancomycin
Filovirus Fungal HY-14882A Cenicriviroc (TAK-652) HY-B0490 Hygromycin B
HBV HCV HY-19930 Vaborbactam (RPX7009) HY-15148 Tipranavir (PNU-140690)
HIV HSV HY-109025 Baloxavir marboxil (S-033188) HY-13986 Merimepodib (VX-497)
Influenza Virus Parasite HY-12320 Cycloheximide (Actidione; CHX) HY-12983 ALS-8112
Reverse Transcriptase HY-17628 Cefiderocol (S-649266) HY-17409 Nystatin
RSV SARS-CoV HY-17565 Bleomycin HY-15303 Pritelivir (BAY 57-1293; AIC316)
Virus Protease HY-15695 Puromycin Aminonucleoside HY-10846 Delamanid (OPC-67683)
HY-18649 Galidesivir (BCX4430) HY-16727 Presatovir (GS-5806)
HY-50101A Mavorixafor (AMD-070 ) HY-10241 Simeprevir (TMC435)
HY-17006 Caspofungin Acetate (MK- 0991) HY-17586 Dalbavancin (BI-397)
HY-B1743A Puromycin (CL13900) HY-15597 Salinomycin (Procoxacin)
HY-17589 Chloroquine HY-14989 SQ109 (NSC722041)
HY-A0098 Tunicamycin HY-13004 Maraviroc (UK-427857)
HY-12594 Paritaprevir (ABT-450) HY-14768 Favipiravir (T-705)
HY-14865C Omadacycline (PTK0796) HY-13238 Dolutegravir (S/GSK1349572)
HY-N0565B Doxycycline HY-112205A RR-11a analog
HY-14434 Asunaprevir (BMS-650032) HY-10493 Cobicistat (GS-9350)
HY-12559 Alisporivir (Debio-025) HY-B0117 Tigecycline (GAR-936)
HY-P0025 NIM811 HY-101954 Inarigivir
HY-13740 Resiquimod (R848) HY-16468 Squalamine (MSI-1256)
HY-16742 Gepotidacin (GSK2140944) HY-15460 CHIR-090
HY-100029 Bay 41-4109 HY-90001 Ritonavir (ABT 538)
HY-14879A Avibactam (NXL-104) HY-15233 Letermovir (AIC246)
HY-104012 Islatravir (MK-8591) HY-B0522A Ampicillin
HY-13318 Oseltamivir acid (GS 4071) HY-16973 Fluralaner (A1443)
HY-14737 Ceftaroline fosamil (TAK-599) HY-101479 Iclaprim (AR-100)
HY-17367A Atazanavir (BMS-232632) HY-10373 Trimetrexate (CI-898)
HY-17605 Bictegravir (GS-9883) HY-B1123 Auranofin (SKF-39162)
HY-15287A Nelfinavir (AG-1343) HY-16980A Eravacycline (TP-434)
HY-17561 G-418 (Geneticin) HY-15298 Grazoprevir (MK-5172)
HY-16752 Relebactam (MK-7655) HY-135747 Gut restricted-7
HY-112579 Ceftobiprole (Ro 63-9141) HY-P0017 Aprotinin
HY-14881 Bedaquiline (TMC207) HY-10392 Sutezolid (PNU-100480)
HY-16730 Sarolaner (PF-6450567) HY-17593 Solithromycin (CEM-101)
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Master of Small Molecules
JAK/STAT Signaling
EGFR JAK Cat. No. Product Name Cat. No. Product Name
Pim STAT HY-19322B PIM-447 (LGH447) HY-104065 Pyrotinib (SHR-1258)
HY-117287 BMS-986165 HY-16069 Tucatinib (Irbinitinib)
HY-P9907 Trastuzumab HY-129550 BI-4020
HY-109053 Delgocitinib (JTE-052) HY-10261 Afatinib (BIBW 2992)
HY-19569 Upadacitinib (ABT-494) HY-15730 Poziotinib (HM781-36B)
HY-15772 Osimertinib (AZD-9291) HY-50895 Gefitinib (ZD1839)
HY-P9905 Cetuximab (C225) HY-100754 PF-06651600
HY-50856 Ruxolitinib (INCB18424) HY-10409 Fedratinib (TG-101348)
HY-16975 SH-4-54 HY-16997 Itacitinib (INCB039110)
HY-112299 TAS6417 HY-50896 Erlotinib (CP-358774)
HY-P9912 Pertuzumab HY-15146 NSC 74859 (S3I-201)
HY-18750 AZD3759 HY-100494 SH5-07
HY-104065B Pyrotinib (SHR-1258) HY-13050 Sapitinib (AZD-8931)
HY-40354 Tofacitinib (CP-690550) HY-16379 Pacritinib (SB1518)
HY-18960 CHZ868 HY-111553 TAS0728
MAPK/ERK Pathway
ERK Cat. No. Product Name Cat. No. Product Name
JNK HY-15605 Encorafenib (LGX818) HY-18972 PLX8394
KLF HY-50846 SCH772984 HY-50706 Selumetinib (AZD6244)
MAP3K HY-10256 SB 203580 HY-10999A Trametinib (GSK-1120212)
MAP4K HY-100022 Tomivosertib (eFT508) HY-14660 Dabrafenib (GSK2118436)
MAPKAPK2 (MK2) HY-12057 Vemurafenib (PLX4032) HY-10254 PD0325901
MEK HY-18938 Selonsertib (GS-4997) HY-10402 Losmapimod (GW856553X)
Mixed Lineage Kinase HY-12028 PD98059 HY-15202 Binimetinib (MEK162)
MNK HY-12031 U0126 HY-12599 URMC-099
p38 MAPK HY-13064 Cobimetinib (GDC-0973) HY-12558 LY3009120 (DP-4978)
Raf HY-10201 Sorafenib (Bay 43-9006) HY-10295 SB 202190
Ribosomal S6 Kinase (RSK) HY-32018 Cot inhibitor-2 HY-12947 GNE-3511
HY-15947 Ravoxertinib (GDC-0994) HY-15816 Ulixertinib (BVD-523)
HY-112082 BAY885 HY-103490 Takinib
HY-10999 Trametinib (GSK1120212) HY-52101 CMK
HY-112089 LXH254 HY-10510 BI-D1870
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Inhibitors • Agonists • Screening Libraries
GPCR/G Protein
Class A: Kisspeptin Receptor Cat. No. Product Name Cat. No. Product Name
Adenosine Receptor Leukotriene Receptor HY-114277 AMG-510 HY-15778 AVE 0991
Adenylate Cyclase LPL Receptor HY-U00418 ARS-1620 HY-15418 RS 504393
Adiponectin Receptor mAChR HY-15677 INT-777 HY-19870 Setmelanotide
Adrenergic Receptor MCHR1 (GPR24) HY-130149 MRTX849 HY-13951 ICI 118,551
Adrenergic Receptor Melanocortin Receptor HY-112185 GLP-1 receptor agonist 1 HY-12355 Siponimod
Angiotensin Receptor Melatonin Receptor HY-12434 INT-767 HY-15848 AdipoRon
Apelin Receptor mGluR HY-13948 Angiotensin II human HY-10017 SCH 546738
Bombesin Receptor Motilin Receptor HY-P0014 Liraglutide HY-P0202 Endothelin 1
Bradykinin Receptor Neurokinin Receptor HY-13245 PF-4136309 HY-101952 Prostaglandin E2
Cannabinoid Receptor Neuromedin U receptor 2 HY-32709 Telcagepant HY-100619 BMS-986020
CaSR Neuropeptide Y Receptor HY-15608 MPTP HY-10198 Navarixin
CCR Neurotensin Receptor HY-50101A Mavorixafor HY-114118A Semaglutide
CGRP Receptor Opioid Receptor HY-15403A Atrasentan HY-111343 ONC212
Cholecystokinin Receptor Orexin (OX) Receptor HY-15252 Reparixin HY-10302 MK-3207
Class A Orphans Oxytocin Receptor HY-13443 Exendin-4 HY-10480 Fasiglifam
CRFR P2Y Receptor HY-101978 CPI-444 HY-B0606 Diquafosol
CXCR Platelet-Activating Factor HY-126247 BI-2852 HY-14870 Selexipag
Dopamine Receptor Receptor HY-114436 MRTX-1257 HY-P0171 Motixafortide
EBI2/GPR183 Prolactin-Releasing Peptide HY-13848 AZD8797 HY-14779 Riociguat
Endothelin Receptor Receptor HY-103088 E7046 HY-B0879A Suramin
Formylpeptide Receptor Prostaglandin Receptor HY-14864 Mapracorat HY-114398 BAY-293
GHSR Protease-Activated HY-15894 BQ-788 HY-A0013 Bosentan
Glucocorticoid Receptor Receptor (PAR) HY-19855 AZD-5069 HY-N0583 Hydrocortisone
GNRH Receptor Ras HY-119243 LY2794193 HY-P0082 Glucagon
GPCR19 RGS Protein HY-15319 AMG 487 HY-100775 Setogepram
GPR109A Sigma Receptor HY-50674 INCB3344 HY-10013 Taranabant
GPR119 Somatostatin Receptor HY-12802 AF38469 HY-12080 BX471
GPR120 TSH Receptor HY-101295 Pan-RAS-IN-1 HY-112558 AZ3451
GPR139 Urotensin Receptor HY-19706 ARS-853 HY-16774 Vericiguat
GPR40 Vasopressin Receptor HY-14648 Dexamethasone HY-103193 NKH477
GPR55 Class B: HY-10095 Olcegepant HY-17000 Tolvaptan
GPR84 Glucagon Receptor HY-101980 AZD4635 HY-19904 Adomeglivant
Guanylate Cyclase VIP and PACAP Receptors HY-16168A Degarelix HY-12378 BQ-123
Histamine Receptor HY-P0264 Avexitide HY-B0075 Melatonin
Imidazoline Receptor HY-108677 L-368,899 HY-U00416 ARS-1323
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 MCE
Master of Small Molecules
Neuronal Signaling
5-HT Receptor AChE Cat. No. Product Name Cat. No. Product Name
Adenosine Kinase HY-17366 Clozapine (N-oxide) HY-15084 Dizocilpine (MK-801)
Adrenergic Receptor HY-A0190 Ceruletide (Caerulein) HY-10448 Capsaicin
Amyloid-? Beta-secretase HY-15424 5-Iodotubercidin (NSC 113939) HY-112723 ACT-709478
Calcium Channel HY-32709 Telcagepant (MK-0974) HY-12449 Crenigacestat (LY3039478)
CaMK HY-15608 MPTP HY-15064 HC-030031
Cannabinoid Receptor HY-107422 PAT-1251 HY-12650 Mirogabalin (DS5565)
CGRP Receptor HY-42110 Deschloroclozapine HY-101386 PZM21
Cholecystokinin Receptor HY-14896 Opicapone (BIA 9-1067) HY-18779 PF-4840154
COMT HY-100740 Lanabecestat (AZD3293) HY-10809 Bitopertin (RG1678)
Dopamine Receptor HY-15498 Rimegepant (BMS-927711) HY-B0468 Isoprenaline (Isoproterenol)
Dopamine Transporter HY-12802 AF38469 HY-14773 Mirabegron (YM178)
FAAH GABA Receptor HY-19608 GSK1016790A HY-16567 Asenapine
GlyT GPR119 HY-10095 Olcegepant (BIBN-4096) HY-P0183 Nociceptin (Orphanin FQ)
GPR139 GPR55 HY-50752 LY-411575 HY-P1061A Colivelin
Histamine Receptor HY-19733 Lumateperone (ITI-007) HY-14557A Pimavanserin (ACP-103)
iGluR HY-103040 Zuranolone HY-19654 GSK598809
Imidazoline Receptor HY-P1363 Amyloid ?-Peptide (1-42) HY-106224 Orexin A
mAChR HY-50682 Azeliragon (TTP488) HY-10341 Fasudil (HA-1077)
MCHR1 (GPR24) HY-101736 AMG9810 HY-13526 YO-01027 (Dibenzazepine; DBZ)
Melanocortin Receptor HY-P0128 Amyloid beta-peptide(25-35) HY-12777 Asivatrep (PAC-14028)
Melatonin Receptor HY-10302 MK-3207 HY-15296 Cabergoline (FCE-21336)
mGluR HY-15068 NBQX (FG9202) HY-19370 FPS-ZM1
Monoamine Oxidase HY-12428 A-1165442 HY-13410 Xanomeline (LY246708)
nAChR HY-101507 Pico145 (HC-608) HY-16725 Lemborexant (E-2006)
Neurokinin Receptor HY-19369 L-685458 HY-12882A Ifenprodil
Neuropeptide Y Receptor HY-N2332A Methyllycaconitine citrate HY-19545A SCH 23390
Neurotensin Receptor HY-108337 GNE 0723 HY-15370A SB-269970
Notch HY-B0102A Fluoxetine (LY-110140) HY-P0117 Tat-NR2B9c (NA-1)
Opioid Receptor HY-100714A D-AP5 HY-101299B Dihydrexidine (DAR-0100)
Orexin Receptor (OX Receptor) HY-14176 Compound E HY-P0201 Substance P
Serotonin Transporter HY-B0075 Melatonin HY-17631A Edonerpic (T-817MA)
Sigma Receptor HY-B0726 Pilocarpine HY-14763A Cariprazine (RGH188)
Somatostatin Receptor HY-14280 Entacapone HY-13438 AZD3839
Trk Receptor TRP Channel HY-12745A Nalfurafine (TRK-820) HY-70059 LY341495
?-secretase HY-108690 Fluxametamide HY-16579A Etifoxine
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Inhibitors • Agonists • Screening Libraries
Membrane Transporter/Ion Channel
ATP Synthase Cat. No. Product Name Cat. No. Product Name
BCRP HY-12750 AZD3965 HY-108337 GNE 0723
Calcium Channel HY-15763 Erastin HY-19778 (R)-BPO-27
CFTR HY-100558 Bafilomycin A1 HY-15699 SAR7334
Chloride Channel HY-100720 GSK2193874 HY-N2143 Fumitremorgin C
CRAC Channel HY-15598 20-HETE HY-112302 HC-070
CRM1 HY-17607 Cenobamate (YKP3089) HY-13017 Ivacaftor (VX-770)
EAAT2 HY-10010 Ko 143 HY-100714A D-AP5
GABA Receptor HY-15409 Empagliflozin (BI 10773) HY-12693 R(+)-IAA-94
GlyT HY-50879 Elacridar (GF120918) HY-101455 CDN1163
HCN Channel HY-111772 Elexacaftor (VX-445) HY-15084 Dizocilpine (MK-801)
iGluR HY-50694 Senicapoc (ICA-17043) HY-10448 Capsaicin
Monoamine Transporter HY-15718A Istaroxime (PST2744) HY-112723 ACT-709478
Monocarboxylate Transporter HY-13248 AR-C155858 HY-12343 ML277 (CID-53347902)
Na+/Ca2+ Exchanger HY-19608 GSK1016790A HY-100965 Diphenyleneiodonium chloride (DPI)
Na+/HCO3- Cotransporter HY-100381 Nigericin HY-15064 HC-030031
Na+/K+ ATPase HY-13433 Thapsigargin HY-12650 Mirogabalin (DS5565)
nAChR HY-100390 (S)-ML753286 HY-50671 Zosuquidar (LY-335979)
NKCC HY-10450 Dapagliflozin (BMS-512148) HY-101840 EIPA (L593754)
P-glycoprotein HY-103040 Zuranolone HY-101664 Ilaprazole (IY-81149)
P2X Receptor HY-15553A Mibefradil (Ro 40-5967) HY-18779 PF-4840154
Potassium Channel HY-101588 Gefapixant (MK-7264) HY-10809 Bitopertin (RG1678)
Proton Pump HY-101736 AMG9810 HY-111651 Gboxin
SGLT HY-10451 Canagliflozin (JNJ 28431754) HY-16738A Eleclazine (GS 6615)
Sodium Channel HY-13434 Ionomycin HY-17384 Valspodar (PSC 833)
TRP Channel HY-101942 CM-4620 HY-12777 Asivatrep (PAC-14028)
URAT1 HY-15068 NBQX (FG9202) HY-12758A YHO-13351
VDAC HY-15640 Capsazepine HY-15258 Lesinurad (RDEA594)
HY-15991 Tenapanor (AZD1722) HY-12882A Ifenprodil
HY-12428 A-1165442 HY-100208 HC-067047
HY-101507 Pico145 (HC-608) HY-14483 AF-353 (Ro-4)
HY-111925 BI-749327 HY-P0117 Tat-NR2B9c (NA-1)
HY-13519 TRAM-34 HY-10634 AMG 517
HY-16589 Oligomycin A (MCH 32) HY-13646 Encequidar (HM30181)
HY-N2332A Methyllycaconitine HY-111325 Synta66
HY-12883 PF 05089771 HY-B1140 Diazoxide (Sch-6783)
11

 MCE
Master of Small Molecules
Cytoskeleton
Arp2/3 Complex Cat. No. Product Name Cat. No. Product Name
Dynamin HY-13442A Eribulin Mesylate HY-19792 Mertansine (DM1)
Gap Junction Protein HY-15575 VcMMAE HY-13441 (-)-Blebbistatin
Integrin HY-15162 Monomethyl auristatin E (MMAE) HY-10913A Danegaptide (GAP-134)
Kinesin HY-15584 Taltobulin (HTI-286; SPA-110) HY-16141 Cilengitide (EMD 121974)
Microtubule/Tubulin HY-10222 Ixabepilone (BMS 247550) HY-14951 Firategrast (SB 683699)
Mps1 HY-15578 McMMAF HY-18676 OSU-T315
Myosin HY-B0015 Paclitaxel (Taxol) HY-15102 MK-0429 (L-000845704)
PAK HY-106268A Larazotide HY-N0488 Vincristine (Leurocristine)
HY-15583 Auristatin F HY-50759 Ispinesib (SB-715992)
HY-15204 Tonabersat (SB-220453) HY-12454 DM4
HY-B0011 Docetaxel (RP-56976) HY-P0023 Cyclo(-RGDfK)
HY-15278 Epothilone D (KOS 862) HY-12793 KPT-9274
HY-15886 Mdivi-1 HY-P0122 iRGD peptide (c(CRGDKGPDC))
HY-17029 Epothilone B (Patupilone) HY-13007 PF-3758309
HY-112162 BOS-172722 HY-12858 Empesertib (BAY 1161909)
NF-?B
IKK Cat. No. Product Name Cat. No. Product Name
Keap1-Nrf2 HY-112433 NIK SMI1 HY-112675 4-Octyl Itaconate
MALT1 HY-12212 Omaveloxolone (RTA-408) HY-P0151 SN50
NF-?B HY-18950 GSK2795039 HY-16561 Resveratrol (SRT501)
Reactive Oxygen Species HY-100523 ML385 HY-13060 ACHP (IKK-2 Inhibitor VIII)
HY-15473 MLN120B HY-B0215 Acetylcysteine (NAC)
HY-12213 CDDO-EA (RTA 405) HY-111941 GSK8612
HY-19356 Rocaglamide (Roc-A) HY-12276 MALT1 inhibitor MI-2
HY-100116A Mitoquinone (MitoQ) HY-18935A CBL0137
HY-101140 KI696 HY-115466 MLT-748
HY-13324 Bardoxolone (RTA 402) HY-B1960 Canthaxanthin
HY-13755 Sulforaphane HY-N0005 Curcumin
HY-D0937 Methoxy-PMS HY-13019 BI605906
HY-13453 BAY 11-7082 (BAY 11-7821) HY-14645 (-)-DHMEQ
HY-15725 CDDO-Im (RTA-403; TP-235) HY-13982 JSH-23
HY-D0940 H2DCFDA HY-10514 BX795
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 www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
TGF-beta/Smad
PKC Cat. No. Product Name Cat. No. Product Name
ROCK HY-10230 Midostaurin (PKC412) HY-13434 Ionomycin (SQ23377)
TGF-beta/Smad HY-13226 Galunisertib (LY2157299) HY-10343 Sotrastaurin (AEB071)
TGF-? Receptor HY-10431 SB-431542 HY-13012 RepSox (E-616452)
HY-10071 Y-27632 HY-103021 LY3200882
HY-15141 Staurosporine HY-N0439 Asiaticoside
HY-12043 SB 525334 HY-12953 R-268712
HY-15307 SLx-2119 (KD-025) HY-P0118 Disitertide (P144)
HY-15392 Chroman 1 HY-10195B Ruboxistaurin (LY 333531)
HY-12075 LY2109761 HY-15685 Ripasudil (K-115)
HY-13013 (E)-SIS3 HY-13689 Go 6983 (Gö 6983)
HY-B0673 Pirfenidone (AMR69) HY-12659 LX7101
HY-100347A SRI-011381 HY-13521 SB-505124
HY-19928 Vactosertib (TEW-7197) HY-13867 Bisindolylmaleimide I
HY-10432 A 83-01 HY-10342 Enzastaurin (LY317615)
HY-12071 LDN193189 (DM-3189) HY-112782 VTX-27
Vitamin D Related
Vitamin D Cat. No. Product Name
Vitamin D Receptor (VDR) HY-10002 Calcitriol (1,25-Dihydroxyvitamin D3)
HY-A0020 Eldecalcitol (ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3)
HY-32343 Secalciferol ((24R)-24,25-Dihydroxyvitamin D3)
HY-15830 25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol)
HY-10001 Calcipotriol (MC 903; Calcipotriene)
HY-50919 Paricalcitol
HY-76915 24, 25-Dihydroxy VD3
HY-77274 Calcitriol Impurities D
HY-15254 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3
HY-76801 24, 25-Dihydroxy VD2 (24,25-Dihydroxy vitamin D2)
HY-32350 Ercalcitriol (1?,25-Dihydroxy Vitamin D2)
HY-32342 Falecalcitriol
HY-15332 Alfacalcidol-D6
HY-32349 Ercalcidiol (25-hydroxy Vitamin D2)
HY-15157 Calcitetrol (1?, 24, 25-Trihydroxy VD3)
13

 MCE
Master of Small Molecules
Antibody-drug Conjugate/ADC Related
The antibody-drug conjugate (ADC) is a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules
(payloads) through chemical linkers. ADCs increase the cell-killing potential of monoclonal antibodies (mAbs), and confer higher tumor selectivity.
Some ADCs has been approved by FDA.
ADC Cytotoxin
Destroys cancer cells
50+
ADC Cytotoxins
Cat. No. Product Name
HY-15162 Monomethyl auristatin E ADC Linker
Joins antibody and drug
HY-15162A D8-MMAE
HY-15584 Taltobulin
HY-15142 Doxorubicin Hydrochloride
HY-13316 Mitomycin C Antibody
Targets cancer cells
HY-19610 alpha-Amanitin
HY-B0015 Paclitaxel
HY-15583 Auristatin F Drug-Linker Conjugates for 500+
HY-16261 Aldoxorubicin ADC ADC Linkers
HY-19609 Calicheamicin Cat. No. Product Name Cat. No. Product Name
HY-19792 Mertansine HY-15575 VcMMAE HY-78738 MC-Val-Cit-PAB
HY-13631D Dxd HY-15578 McMMAF HY-12362 Val-cit-PAB-OH
HY-13062 Daunorubicin Hydrochloride HY-101070 SMCC-DM1 HY-41189 Fmoc-Val-Cit-PAB-PNP
HY-14519 Methotrexate HY-13631E Deruxtecan HY-20336 Mc-Val-Cit-PABC-PNP
HY-13704 SN-38 HY-100374 Val-Cit-PAB-MMAE HY-43869 Vipivotide tetraxetan Linker
HY-15579A MMAF Hydrochloride HY-111012 DBCO-(PEG)3-VC-PAB-MMAE HY-42973 DBCO-NHS ester
HY-16700 PNU-159682 HY-100566 SuO-Val-Cit-PAB-MMAE HY-114430 Fmoc-Phe-Lys(Boc)-PAB-PNP
HY-13061 Daun02 HY-117410 Vipivotide tetraxetan HY-100216 SPDP
HY-15579AS D8-MMAF Hydrochloride HY-126681 SC-VC-PAB-MMAE HY-19318 Fmoc-Val-Cit-PAB
HY-16560 Camptothecin