brochure des produits bioactifs par MCE

MCE - Master of Bioactive Molecules

Inhibitors • Screening Libraries • Proteins

Dark Quenchers

• BHQ1
• BHQ2
• BHQ3
• DabcyI
• Eclipse

Related Popular Products

• HY-147080 Avacincaptad pegol sodium: an anti-C5 RNA aptamer that inhibits the cleavage of complement factor 5 (C5) into C5a and C5b.
• HY-150751 ODN TTAGGG: a TLR9, AIM2, and cGAS antagonist, used in the study of lupus erythematosus and other related autoimmune diseases.
• HY-150741 ODN 2216: A TLR-9 agonist, used as vaccine adjuvant. CpG ODN

Degenerate Bases

• IUB Base Codes: B=C/G/T, D-A/G/T, H=A/C/T, I=Universal Base
• Targets nucleolin, has anti-tumor activity: HY-147081 AS 1411 Aptamer
• Reduces hepatic oxalate production by targeting glycolate oxidase: HY-132588 Lumasiran siRNA

Attachment Chemistry / Linkers Modifications

• Acrydite
• Aldehyde
• Alkyne
• Amino
• Azide
• Biotin
• Carboxy
• COOH
• DBCO
• Digoxin
• Maleimide
• Thiol

Spacers Modifications

• C3 Spacer
• C6 Spacer
• C12 Spacer
• dSpacer
• PC-linker
• Spacer 18
• Spacer 9

Modified Bases

• 2' Fluoro bases
• 2-O-Methyl Base
• 2-Aminopurine
• 5-Aza-2'-dC
• 5-Bromo dU
• 5-Hydroxymethyl dC
• 5-Methyl dC
• 5-Nitroindole
• 8-Oxo
• deoxyInosine
• DeoxyUridine
• Dideoxycytidine
• Inverted dG
• Inverted dT
• LNA
• N6 Methyl dA
• phosphorothioate
• Phosphorylation
• Pyrrolo-dC

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RNA Therapy: A Break-through for ‘Undruggable-target’ Limitations

SiRNAs are small exogenous double-stranded RNA (dsRNA) (20-25 nucleotides), which triggers the RNA interference (RNAi) pathway. The short dsRNA unwinds, and the sense strand is degraded. Antisense strand forms RNA-induced silencing complex (RISC) with various protein components. The antisense strand retained in RISC is specifically complementary to the target gene mRNA. Meanwhile, RISC has nuclease activity, which can cut and degrade the target gene mRNA and inhibit the expression of the target gene. Incomplete complementarity results in mRNA translation inhibition.

MicroRNAs (miRNAs) are endogenous non-coding RNAs that contain approximately 22 nucleotides, and their primary function is to mediate gene silencing. miRNAs usually bind to 3'-UTR of mRNA. For mammals, the base-pairing is always imperfect, resulting in the suppression of mRNA translation. In contrast, most plant miRNAs bind with near-perfect complementarity to sites within the coding sequence of their targets, and the mRNA of the target gene is sliced and degraded. In addition, miRNAs can have multiple targets, because they act through less complementarity.

Advantages of oligonucleotides:

• Improved transport into cells
• Lower cost
• Comprehensive modifications
• Reliable quality data
• Powerful capacity
• Professional technical support

MCE offers more than 100 modifications (only some commonly used modifications are listed).

References

• [1] Front Bioeng Biotechnol. 2021;9:628137.
• [2] J Neuromuscul Dis. 2020;7(1):1-13.
• [3] Chonnam Med J. 2020;56(2):87-93.
• [4] Nat Nanotechnol. 2021;16(6):630-643.
• [5] Nat Rev Neurol. 2018;14(1):9-21.
• [6] Adv Drug Deliv Rev. 2020;154-155:37-63.
• [7] Nat Rev Genet. 2022 May;23(5):265-280.
• [8] Mol Cancer. 2021;20(1):54.
• [9] Cells. 2020;9(1):137.
• [10] Adv Drug Deliv Rev. 2018;134:65-78.