Document
MCE Inhibitors & Agonists & Compound libraries(1)-compressé
Contenu du document
www.MedChemExpress.com
MedChemExpress
Inhibitors & Agonists
25,000+ Speci?c Inhibitors & Agonists Targeting 20+ Classic Signaling Pathways
Compound Screening Libraries
50+ Compound Screening Libraries Optimized for Disease Mechanism Revealing & Drug Repurposing
Publications Citing Use of MCE Products Nature. 2020 Apr;580(7803):386-390.
Cell. 2020 Apr 6. pii: S0092-8674(20)30268-3.
Cell. 2020 Mar 5;180(5):941-955.e20.
Nature. 2020 Mar;579(7799):433-437.
Science. 2020 Feb 14;367(6479):806-810.
Cell. 2020 Feb 20;180(4):645-654.e13.
Nature. 2019 Dec;576(7786):274-280.
Cell. 2019 Dec 12;179(7):1483-1498.e22.
Cell. 2019 Dec 12;179(7):1566-1581.e16.
Nature. 2019 Nov;575(7782):375-379.
Nature. 2019 Nov;575(7784):683-687.
Nature. 2019 Oct;574(7777):264-267.
Cell. 2019 Oct 31;179(4):864-879.e19.
Nat Nanotechnol. 2019 Oct;14(10):988-993.
Nat Biotechnol. 2019 Oct;37(10):1209-1216.
Cell. 2019 Aug 22;178(5):1145-1158.e20.
Cell. 2019 Aug 22;178(5):1132-1144.e10.
Nature. 2019 Jul;571(7763):127-131.
Science. 2019 Jul 19;365(6450).
Cell. 2019 Jul 25;178(3):585-599.e15.
Cell. 2019 Jul 11;178(2):330-345.e22.
“ Inhibitors & Agonists
We offer 25,000+ selective Inhibitors and Agonists
Targeting 375 key proteins in 20+ signaling pathways
only the Applications in different disease areas
highest-
Screening Libraries
grade MCE Compound Screening Libraries consist of
products! 10,000+ small molecules with
validated biological and pharmacological activities
Quality
Our robust quality control methods assure
product high quality and purity.
Experience
We track the latest scienti?c innovations and
provide you access to the newest compounds.
Validation
Our products biological activities are validated Natur e
Scien ce Ce ll
by worldwide customers and published in the
top scienti?c journals.
Partner
We work together with renowned research
www.MedChemExpress.com institutes and pharmaceutical companies.
Table of Contents Signaling Pathways
PI3K/Akt/mTOR 1
Epigenetics 1
Autophagy 2
Apoptosis 2
Cell Cycle/DNA Damage 3
Metabolic Enzyme/Protease 4
Protein Tyrosine Kinase/RTK 5
Immunology/Inflammation 6
Stem Cell/Wnt 6
Anti-infection 7
JAK/STAT Signaling 8
MAPK/ERK Pathway 8
GPCR/G Protein 9
Neuronal Signaling 10
Membrane Transporter/Ion Channel 11
Cytoskeleton 12
NF-?B 12
TGF-beta/Smad 13
VD/VDR 13
Antibody-drug Conjugate/ADC Related 14
PROTAC 15
Compound Screening Libraries 16
Virtual Screening 19
Dye Reagents 22
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
PI3K/Akt/mTOR
Akt AMPK Cat. No. Product Name Cat. No. Product Name
ATM/ATR DNA-PK HY-10219 Rapamycin (Sirolimus) HY-13003 Torin 1
GSK-3 MELK HY-15244 Alpelisib HY-15186 Ipatasertib (GDC-0068; RG7440)
mTOR PDK-1 HY-19312 3-Methyladenine (3-MA) HY-13522 Fimepinostat (CUDC-907)
PI3K PI4K HY-10182 CHIR-99021 HY-70063 Buparlisib (BKM120)
PIKfyve PTEN HY-10108 LY294002 HY-13002 Torin 2
HY-10358 MK-2206 HY-13417 AICAR
HY-19323 Ceralasertib (AZD6738) HY-101566A BAY-1895344
HY-12513 LY3023414 HY-P0175 740 Y-P
HY-10218 Everolimus (RAD001) HY-10422 AZD-8055
HY-101562 GDC-0077 HY-13026 Idelalisib (CAL-101; GS-1101)
HY-101570 Nedisertib HY-19939S VX-984
HY-15346 Copanlisib HY-10514 BX795
HY-13902 Berzosertib (VE-822; VX-970) HY-15512A OTSSP167
HY-15431 Capivasertib (AZD5363) HY-13074 VO-Ohpic
HY-17471A Metformin HY-12046 PIK-93
Epigenetics
AMPK Cat. No. Product Name Cat. No. Product Name
Aurora Kinase HY-13030 (+)-JQ-1 HY-15149 Romidepsin (FK 228)
DNA Methyltransferase HY-15743 Birabresib (OTX-015; MK-8628) HY-15145 SRT 1720
Epigenetic Reader Domain HY-13803 Tazemetostat (EPZ-6438) HY-12635 SP2509
HDAC HY-13470 GSK126 HY-108696 GNE-781
Histone Acetyltransferase HY-107455 A-485 HY-A0004 Decitabine (5-Aza-2'-deoxycytidine)
Histone Demethylase HY-104048 QC6352 HY-13980 UNC0642
Histone Methyltransferase HY-101563 GSK3326595 HY-15452 Selisistat (EX-527)
JAK HY-15144 Trichostatin A (TSA) HY-111048 Corin
MicroRNA HY-15229 Guadecitabine (SGI-110) HY-13235 I-BET151
PARP HY-13032 Molibresib (I-BET762; GSK525762) HY-100482 CPI-637
PKC HY-103713 Seclidemstat (SP-2577) HY-12186 3-Deazaneplanocin A (DZNep)
Protein Arginine Deiminase HY-13418 Dorsomorphin (Compound C) HY-100514 GSK484
Sirtuin HY-15648B GSK-J4 HY-16425 RG2833
HY-101564 JNJ-64619178 HY-12163 Entinostat (MS-275)
HY-16925 MI-503 HY-10224 Panobinostat (LBH589)
1
MCE
Master of Small Molecules
Autophagy
Autophagy FKBP Cat. No. Product Name Cat. No. Product Name
LRRK2 Mitophagy HY-11109 Resatorvid (TAK-242) HY-10971 Alisertib (MLN8237?
ULK HY-10162 Olaparib (AZD2281) HY-B0015 Paclitaxel (Taxol)
HY-100411 MLi-2 HY-17559 Actinomycin D
HY-70002 Enzalutamide (MDV3100) HY-17394 Cisplatin (CDDP)
HY-B0146 Verteporfin HY-15371 Forskolin (Coleonol)
HY-13756 Tacrolimus (FK506; Fujimycin) HY-17371 Oxaliplatin
HY-13992 AP20187 HY-13636 Fulvestrant (ICI 182780)
HY-13259 MG-132 HY-12481 SAR405
HY-19312 3-Methyladenine (3-MA) HY-100006A MRT68921
HY-13251 Silvestrol HY-16966 SBI-0206965
HY-12320 Cycloheximide (Actidione; CHX) HY-13018 MRT67307
HY-10108 LY294002 HY-100941 CCCP
HY-15142 Doxorubicin HY-16592 Brefeldin A (BFA)
HY-100558 Bafilomycin A1 HY-12990 Spautin-1
HY-50856 Ruxolitinib (INCB18424) HY-10129 Veliparib (ABT-888)
Apoptosis
Apoptosis Bcl-2 Family Cat. No. Product Name Cat. No. Product Name
c-Myc Caspase HY-100741 S63845 HY-100579 Ferrostatin-1
DAPK Ferroptosis HY-10087 Navitoclax (ABT-263) HY-16046 Rimiducid (AP1903)
FKBP IAP HY-13756 Tacrolimus (FK506; Fujimycin) HY-F0003 NADPH
MDM-2/p53 PKD HY-13992 AP20187 (B/B Homodimerizer) HY-101565 AMG-176
RIP Kinase Survivin HY-16658 Z-VAD(OMe)-FMK HY-101297 Z-IETD-FMK
Thymidylate Synthase HY-15763 Erastin HY-18658 Siremadlin (HDM 201)
TNF Receptor HY-13205 Belnacasan (VX-765) HY-19741 A-1331852
HY-15676 Idasanutlin (RG7388) HY-12466 Z-DEVD-FMK
HY-114481 Imidazole ketone erastin (IKE) HY-102080 SAFit2
HY-12296 AMG 232 HY-12726 Liproxstatin-1
HY-50936 Trabectedin (ET-743) HY-12635 SP2509
HY-15531 Venetoclax (ABT-199; GDC-0199) HY-13002 Torin 2
HY-12305 Q-VD-OPh (QVD-OPH? HY-50907 ABT-737
HY-15518 LCL161 HY-16591 Birinapant
HY-10959 RG7112 HY-10396 Emricasan (PF 03491390)
2
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
Cell Cycle/DNA Damage
Antifolate Cat. No. Product Name Cat. No. Product Name
APC HY-13631A Exatecan HY-16592 Brefeldin A (BFA)
ATM/ATR HY-13442A Eribulin Mesylate HY-12137 Volasertib (BI 6727)
Aurora Kinase HY-10162 Olaparib (AZD2281) HY-16209 Forodesine (BCX-1777)
Casein Kinase HY-10619 Niraparib (MK-4827) HY-101212 CYC065
CDK HY-114177 PF-06873600 HY-103618 THZ531
Checkpoint Kinase (Chk) HY-16737 Elafibranor (GFT505) HY-13624A Epirubicin (4'-Epidoxorubicin)
CRISPR/Cas9 HY-15162 Monomethyl auristatin E (MMAE) HY-50855 Silmitasertib (CX-4945)
Deubiquitinase HY-13251 Silvestrol HY-50935 Troglitazone (CS-045)
DNA Alkylator/Crosslinker HY-12320 Cycloheximide (Actidione; CHX) HY-17371 Oxaliplatin
DNA-PK HY-16297 Abemaciclib (LY2835219) HY-104044 Pamiparib (BGB-290)
DNA/RNA Synthesis HY-10993 Adavosertib (AZD1775; MK-1775) HY-16261 Aldoxorubicin (INNO-206)
Eukaryotic Initiation Factor (eIF) HY-10617 Rucaparib (AG-014699) HY-80013 THZ1
G-quadruplex HY-50767 Palbociclib (PD 0332991) HY-101566A BAY-1895344
Haspin Kinase HY-13316 Mitomycin C (Ametycine) HY-112162 BOS-172722
HDAC HY-19323 Ceralasertib (AZD6738) HY-10129 Veliparib (ABT-888)
HSP HY-103712A Samuraciclib (CT7001) HY-12214A NVP-2
IRE1 HY-112088 AZD4573 HY-13469 Debio 0932 (CUDC-305)
Kinesin HY-16106 Talazoparib (BMN-673) HY-19831 4EGI-1
LIM Kinase (LIMK) HY-17565 Bleomycin HY-13753 Streptozocin (Streptozotocin)
Microtubule/Tubulin HY-112654 GCN2iB HY-B0779 Teprenone (Geranylgeranylacetone)
Mps1 HY-10971 Alisertib (MLN 8237) HY-12871B Atuveciclib (BAY-1143572)
Nucleoside Antimetabolite/Analog HY-12037 Rigosertib (ON-01910) HY-15372 GW 6471
p97 HY-B0015 Paclitaxel (Taxol) HY-114258 LY3295668 (AK-01)
PAK HY-17559 Actinomycin D HY-90006 5-Fluorouracil (5-FU)
PARP HY-104040 MKC8866 HY-30237 Seliciclib (Roscovitine; CYC202)
PERK HY-19620 Branaplam (LMI070) HY-15725 CDDO-Im (RTA-403)
Polo-like Kinase (PLK) HY-17394 Cisplatin (CDDP) HY-100888 Simurosertib (TAK-931)
PPAR HY-101570 Nedisertib (M3814) HY-18682 Centrinone (LCR-263)
RAD51 HY-10211 Tanespimycin (17-AAG) HY-18072 GSK2606414
ROCK HY-13902 Berzosertib (VE-822; VX-970) HY-17618 Pemafibrate
Sirtuin HY-15777 Ribociclib (LEE011) HY-107986 GNE-6776
SRPK HY-109101 Risdiplam (RG7916; RO7034067) HY-12861 CB-5083
Telomerase HY-18174 Prexasertib (LY2606368) HY-130250 SR-4835
TOPK HY-17364 Temozolomide (TMZ) HY-15147 XAV-939
Topoisomerase HY-10492 Dinaciclib (SCH 727965) HY-13323 CX-5461
3
MCE
Master of Small Molecules
Metabolic Enzyme/Protease
Oxidoreductases: Elastase Cat. No. Product Name Cat. No. Product Name
5 alpha Reductase Factor Xa HY-12248 Telaglenastat HY-10227 Bortezomib
5'-Deiodinase Glucosidase HY-12222 Obeticholic acid HY-N0565B Doxycycline
Aldehyde Dehydrogenase MAGL HY-16901 Firsocostat HY-101560 Linrodostat
Aldose Reductase MMP HY-13756 Tacrolimus HY-14434 Asunaprevir
Cytochrome P450 Neprilysin HY-70062 Pevonedistat HY-15193 EMD638683
Dopamine ?-hydroxylase Phosphatase HY-13259 MG-132 HY-P0025 NIM811
Glutathione Peroxidase Phosphodiesterase (PDE) HY-19312 3-Methyladenine HY-B0764 Bucladesine
HIF/HIF Prolyl-Hydroxylase Phospholipase HY-12219A MSI-1436 HY-100116A Mitoquinone
HMG-CoA Reductase Proteasome HY-15689 Epacadostat HY-13426 Roxadustat
Indoleamine 2,3-Dioxygenase Renin HY-12867 PT-2385 HY-120384 AZD-0284
Isocitrate Dehydrogenase Soluble Epoxide Hydrolase HY-109083 Cilofexor HY-50876 (E)-Daporinad
Lactate Dehydrogenase Thrombin HY-18657 TEPP-46 HY-112929 DT-061
Lipoxygenase Lyases: HY-116009 RMC-4550 HY-108697 PT2399
NADPH Oxidase Carbonic Anhydrase HY-101979A CB-1158 HY-50108 GW 4064
Stearoyl-CoA Desaturase Decarboxylase HY-15424 5-Iodotubercidin HY-17367A Atazanavir
Tryptophan Hydroxylase Enolase HY-107418 Tropifexor HY-17605 Bictegravir
Tyrosinase Ligase: HY-12434 INT-767 HY-13966 2-Deoxy-D-glucose
Xanthine Oxidase Acetyl-CoA Carboxylase HY-15676 Idasanutlin HY-D0937 Methoxy-PMS
Transferases: Isomerase HY-12296 AMG 232 HY-18767 Ivosidenib
COMT Others: HY-100388 SHP099 HY-14771A Imeglimin
Acyltransferase CETP HY-18770B Navoximod HY-10502 Tipifarnib
Carbohydrate transferase Drug Metabolite HY-112645 BAY-2402234 HY-15287A Nelfinavir
E1/E2/E3 Enzyme Endogenous Metabolite HY-101842 ND-646 HY-13469 Debio 0932
Farnesyl Transferase FXR HY-104037 Cintirorgon HY-10912 Fexaramine
Fatty Acid Synthase (FAS) HCV Protease HY-101772 Ziritaxestat HY-14992 Bay 60-7550
Gutathione S-transferase HIV Integrase HY-18950 GSK2795039 HY-B0779 Teprenone
Nampt HIV Protease HY-15371 Forskolin HY-15768 Ilomastat
Pyruvate Kinase LXR HY-16278 Pradigastat HY-104042 Vorasidenib
Hydrolases: Mineralocorticoid Receptor HY-100218A RSL3 HY-15760 Necrostatin-1
Ester hydrolase Mitochondrial Metabolism HY-12270 T-5224 HY-109011 Rosiptor
Adenosine Deaminase RAR/RXR HY-B0763 Ibudilast HY-15148 Tipranavir
Aminopeptidase Reactive Oxygen Species HY-125840 PT2977 HY-13233A Talabostat
ACE ROR HY-100337 WWL70 HY-100742A (R)-GNE-140
Cathepsin Ser/Thr Protease HY-14896 Opicapone HY-100487 TAK-243
Dipeptidyl Peptidase HY-122218 JHU-083 HY-10231 PX-478
4
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
Protein Tyrosine Kinase/RTK
Receptor Tyrosine Kinases Cat. No. Product Name Cat. No. Product Name
(RTKs): HY-16749 Pexidartinib (PLX-3397) HY-12050 CP-673451
ALK HY-112301 Pralsetinib (BLU-667) HY-12289 Defactinib (VS-6063)
c-Fms HY-P9907 Trastuzumab HY-18007 ALW-II-41-27
c-Kit HY-10997 Ibrutinib (PCI-32765) HY-100492 Fisogatinib (BLU-554)
c-Met/HGFR HY-114153 PLX5622 HY-101474A Zanubrutinib (BGB-3111)
Discoidin Domain Receptor HY-12768 BLZ945 HY-10181 Dasatinib (BMS-354825)
EGFR HY-109078 Vecabrutinib (SNS-062) HY-13342 Apatinib (YN968D1)
Ephrin Receptor HY-15150 Bemcentinib (R428; BGB324) HY-101916 Heparan
FGFR HY-16961 Sitravatinib (MGCD516) HY-129550 BI-4020
FLT3 HY-15772 Osimertinib (AZD-9291) HY-13024 Rebastinib (DCC-2036)
IGF-1R HY-P9905 Cetuximab (C225) HY-13016 Cabozantinib (XL184)
Insulin Receptor HY-P9906 Bevacizumab HY-10261 Afatinib (BIBW 2992)
PDGFR HY-10374 Semaxinib (SU5416) HY-15730 Poziotinib (HM781-36B)
RET HY-112306 Ripretinib (DCC-2618) HY-50895 Gefitinib (ZD1839)
ROS HY-10981 Lenvatinib (E7080) HY-10191 Linsitinib (OSI-906)
TAM Receptor HY-50904 Nintedanib (BIBF 1120) HY-13001 Quizartinib (AC220)
Trk Receptor HY-112299 TAS6417 HY-12823 BLU9931
VEGFR HY-109099 Pemigatinib (INCB054828) HY-101568 Roblitinib (FGF-401)
HY-18708 Erdafitinib (JNJ-42756493) HY-12866A Larotrectinib (LOXO-101)
HY-17600 Acalabrutinib (ACP-196) HY-112215 ARQ 531
Non-Receptor Tyrosine Kinases HY-P9912 Pertuzumab HY-13223 Crenolanib (CP-868596)
(NRTKs): HY-12432 Gilteritinib (ASP2215) HY-101549 MRX-2843 (UNC2371)
Ack1 HY-18750 AZD3759 HY-128757 Remibrutinib
Bcr-Abl HY-101977 Selitrectinib (LOXO-195) HY-15514A Merestinib (LY2801653)
BMX Kinase HY-100818 Futibatinib (TAS-120) HY-15458 SAR131675
Btk HY-13311 Infigratinib (BGJ-398) HY-15959 Savolitinib (Volitinib; AZD-6094)
FAK HY-114370 Selpercatinib (LOXO-292) HY-11092 BMS-509744
Itk HY-101561 Avapritinib (BLU-285) HY-109086 Edicotinib (JNJ-40346527)
Pyk2 HY-P0035 Insulin (human) HY-103022 Repotrectinib (TPX-0005)
Src HY-100342 Ibrutinib-biotin HY-10200 BMS-754807
Syk HY-104065 Pyrotinib (SHR-1258) HY-12857 Brigatinib (AP-26113)
HY-16069 Tucatinib (Irbinitinib; ONT-380) HY-50878 Crizotinib (PF-02341066)
HY-12215 Lorlatinib (PF-06463922) HY-19834 Fenebrutinib (GDC-0853)
HY-10331 Regorafenib (BAY 73-4506) HY-15764A A 419259 (RK 20449)
HY-100867A TAK-659 HY-101215 Evobrutinib (M2951)
5
MCE
Master of Small Molecules
Immunology/Inflammation
Aryl Hydrocarbon Receptor Cat. No. Product Name Cat. No. Product Name
CCR CD73 HY-12885B ADU-S100 (MIW815) HY-10218 Everolimus (RAD001)
Complement System HY-10037 Quiflapon (MK591) HY-15776 HG-9-91-01
COX CXCR HY-117287 BMS-986165 HY-101147 YKL-05-099
FKBP FLAP HY-11109 Resatorvid (TAK-242) HY-16046 Rimiducid (AP1903)
Galectin IFNAR HY-14882A Cenicriviroc (TAK-652) HY-17589 Chloroquine Phosphate
Interleukin Related HY-13756 Tacrolimus (FK506; Fujimycin) HY-B0579 Cyclosporin A (Cyclosporine)
IRAK MyD88 HY-12815A MCC950 (CP-456773; CRID3) HY-17627 Avacopan (CCX168)
NO Synthase HY-13992 AP20187 HY-108730 Avelumab
NOD-like Receptor (NLR) HY-P9904 Atezolizumab HY-102080 SAFit2
PD-1/PD-L1 PGE Synthase HY-18739 Phorbol 12-myristate 13-acetate HY-109044 Tapinarof (GSK2894512)
Reactive Oxygen Species HY-50937 ST 2825 HY-13740 Resiquimod (R848)
Salt-inducible Kinase (SIK) HY-112921B diABZI STING agonist-1 HY-109104 Telratolimod (MEDI 9197; 3M-052)
SPHK STING HY-10964 Vadimezan (DMXAA; ASA-404) HY-100116A Mitoquinone
Thrombopoietin Receptor HY-13245 PF-4136309 (INCB8761) HY-50674 INCB3344
Toll-like Receptor (TLR) HY-19745 BMS-202 HY-P9903 Nivolumab (BMS-936558)
Stem Cell/Wnt
Casein Kinase ERK Cat. No. Product Name Cat. No. Product Name
Gli GSK-3 HY-B0146 Verteporfin (CL 318952) HY-15147 XAV-939
Hedgehog Hippo (MST) HY-10182 CHIR-99021 (CT99021) HY-12681 CCT251545
JAK Notch HY-10071 Y-27632 HY-13418A Dorsomorphin (Compound C)
Oct3/4 PKA HY-16975 SH-4-54 HY-109049 Adavivint (SM04690)
Porcupine ROCK HY-50846 SCH772984 HY-19369 L-685458
sFRP-1 Smo HY-17545 LGK974 (WNT974) HY-116830 BRD0705
STAT TGF-beta/Smad HY-100526 XMU-MP-1 HY-13257 Thiazovivin
Wnt YAP HY-15307 SLx-2119 (KD-025) HY-11102 RO4929097 (RG-4733)
?-catenin ?-secretase HY-15392 Chroman 1 HY-14176 Compound E
HY-13027 DAPT (GSI-IX) HY-10590 TWS119
HY-14428 ICG-001 HY-16294 LY2090314
HY-50752 LY-411575 HY-14443 XMD8-92
HY-17024 Cyclopamine (11-Deoxojervine) HY-100830 NCB-0846
HY-15185 Nirogacestat (PF-3084014) HY-15659 Wnt-C59 (C59)
HY-13901 GANT 61 (NSC 136476) HY-10046 Plerixafor (AMD 3100)
6
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
Anti-infection
Arenavirus Bacterial Cat. No. Product Name Cat. No. Product Name
CMV Enterovirus HY-104077 Remdesivir (GS-5734) HY-17362 Vancomycin
Filovirus Fungal HY-14882A Cenicriviroc (TAK-652) HY-B0490 Hygromycin B
HBV HCV HY-19930 Vaborbactam (RPX7009) HY-15148 Tipranavir (PNU-140690)
HIV HSV HY-109025 Baloxavir marboxil (S-033188) HY-13986 Merimepodib (VX-497)
Influenza Virus Parasite HY-12320 Cycloheximide (Actidione; CHX) HY-12983 ALS-8112
Reverse Transcriptase HY-17628 Cefiderocol (S-649266) HY-17409 Nystatin
RSV SARS-CoV HY-17565 Bleomycin HY-15303 Pritelivir (BAY 57-1293; AIC316)
Virus Protease HY-15695 Puromycin Aminonucleoside HY-10846 Delamanid (OPC-67683)
HY-18649 Galidesivir (BCX4430) HY-16727 Presatovir (GS-5806)
HY-50101A Mavorixafor (AMD-070 ) HY-10241 Simeprevir (TMC435)
HY-17006 Caspofungin Acetate (MK- 0991) HY-17586 Dalbavancin (BI-397)
HY-B1743A Puromycin (CL13900) HY-15597 Salinomycin (Procoxacin)
HY-17589 Chloroquine HY-14989 SQ109 (NSC722041)
HY-A0098 Tunicamycin HY-13004 Maraviroc (UK-427857)
HY-12594 Paritaprevir (ABT-450) HY-14768 Favipiravir (T-705)
HY-14865C Omadacycline (PTK0796) HY-13238 Dolutegravir (S/GSK1349572)
HY-N0565B Doxycycline HY-112205A RR-11a analog
HY-14434 Asunaprevir (BMS-650032) HY-10493 Cobicistat (GS-9350)
HY-12559 Alisporivir (Debio-025) HY-B0117 Tigecycline (GAR-936)
HY-P0025 NIM811 HY-101954 Inarigivir
HY-13740 Resiquimod (R848) HY-16468 Squalamine (MSI-1256)
HY-16742 Gepotidacin (GSK2140944) HY-15460 CHIR-090
HY-100029 Bay 41-4109 HY-90001 Ritonavir (ABT 538)
HY-14879A Avibactam (NXL-104) HY-15233 Letermovir (AIC246)
HY-104012 Islatravir (MK-8591) HY-B0522A Ampicillin
HY-13318 Oseltamivir acid (GS 4071) HY-16973 Fluralaner (A1443)
HY-14737 Ceftaroline fosamil (TAK-599) HY-101479 Iclaprim (AR-100)
HY-17367A Atazanavir (BMS-232632) HY-10373 Trimetrexate (CI-898)
HY-17605 Bictegravir (GS-9883) HY-B1123 Auranofin (SKF-39162)
HY-15287A Nelfinavir (AG-1343) HY-16980A Eravacycline (TP-434)
HY-17561 G-418 (Geneticin) HY-15298 Grazoprevir (MK-5172)
HY-16752 Relebactam (MK-7655) HY-135747 Gut restricted-7
HY-112579 Ceftobiprole (Ro 63-9141) HY-P0017 Aprotinin
HY-14881 Bedaquiline (TMC207) HY-10392 Sutezolid (PNU-100480)
HY-16730 Sarolaner (PF-6450567) HY-17593 Solithromycin (CEM-101)
7
MCE
Master of Small Molecules
JAK/STAT Signaling
EGFR JAK Cat. No. Product Name Cat. No. Product Name
Pim STAT HY-19322B PIM-447 (LGH447) HY-104065 Pyrotinib (SHR-1258)
HY-117287 BMS-986165 HY-16069 Tucatinib (Irbinitinib)
HY-P9907 Trastuzumab HY-129550 BI-4020
HY-109053 Delgocitinib (JTE-052) HY-10261 Afatinib (BIBW 2992)
HY-19569 Upadacitinib (ABT-494) HY-15730 Poziotinib (HM781-36B)
HY-15772 Osimertinib (AZD-9291) HY-50895 Gefitinib (ZD1839)
HY-P9905 Cetuximab (C225) HY-100754 PF-06651600
HY-50856 Ruxolitinib (INCB18424) HY-10409 Fedratinib (TG-101348)
HY-16975 SH-4-54 HY-16997 Itacitinib (INCB039110)
HY-112299 TAS6417 HY-50896 Erlotinib (CP-358774)
HY-P9912 Pertuzumab HY-15146 NSC 74859 (S3I-201)
HY-18750 AZD3759 HY-100494 SH5-07
HY-104065B Pyrotinib (SHR-1258) HY-13050 Sapitinib (AZD-8931)
HY-40354 Tofacitinib (CP-690550) HY-16379 Pacritinib (SB1518)
HY-18960 CHZ868 HY-111553 TAS0728
MAPK/ERK Pathway
ERK Cat. No. Product Name Cat. No. Product Name
JNK HY-15605 Encorafenib (LGX818) HY-18972 PLX8394
KLF HY-50846 SCH772984 HY-50706 Selumetinib (AZD6244)
MAP3K HY-10256 SB 203580 HY-10999A Trametinib (GSK-1120212)
MAP4K HY-100022 Tomivosertib (eFT508) HY-14660 Dabrafenib (GSK2118436)
MAPKAPK2 (MK2) HY-12057 Vemurafenib (PLX4032) HY-10254 PD0325901
MEK HY-18938 Selonsertib (GS-4997) HY-10402 Losmapimod (GW856553X)
Mixed Lineage Kinase HY-12028 PD98059 HY-15202 Binimetinib (MEK162)
MNK HY-12031 U0126 HY-12599 URMC-099
p38 MAPK HY-13064 Cobimetinib (GDC-0973) HY-12558 LY3009120 (DP-4978)
Raf HY-10201 Sorafenib (Bay 43-9006) HY-10295 SB 202190
Ribosomal S6 Kinase (RSK) HY-32018 Cot inhibitor-2 HY-12947 GNE-3511
HY-15947 Ravoxertinib (GDC-0994) HY-15816 Ulixertinib (BVD-523)
HY-112082 BAY885 HY-103490 Takinib
HY-10999 Trametinib (GSK1120212) HY-52101 CMK
HY-112089 LXH254 HY-10510 BI-D1870
8
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
GPCR/G Protein
Class A: Kisspeptin Receptor Cat. No. Product Name Cat. No. Product Name
Adenosine Receptor Leukotriene Receptor HY-114277 AMG-510 HY-15778 AVE 0991
Adenylate Cyclase LPL Receptor HY-U00418 ARS-1620 HY-15418 RS 504393
Adiponectin Receptor mAChR HY-15677 INT-777 HY-19870 Setmelanotide
Adrenergic Receptor MCHR1 (GPR24) HY-130149 MRTX849 HY-13951 ICI 118,551
Adrenergic Receptor Melanocortin Receptor HY-112185 GLP-1 receptor agonist 1 HY-12355 Siponimod
Angiotensin Receptor Melatonin Receptor HY-12434 INT-767 HY-15848 AdipoRon
Apelin Receptor mGluR HY-13948 Angiotensin II human HY-10017 SCH 546738
Bombesin Receptor Motilin Receptor HY-P0014 Liraglutide HY-P0202 Endothelin 1
Bradykinin Receptor Neurokinin Receptor HY-13245 PF-4136309 HY-101952 Prostaglandin E2
Cannabinoid Receptor Neuromedin U receptor 2 HY-32709 Telcagepant HY-100619 BMS-986020
CaSR Neuropeptide Y Receptor HY-15608 MPTP HY-10198 Navarixin
CCR Neurotensin Receptor HY-50101A Mavorixafor HY-114118A Semaglutide
CGRP Receptor Opioid Receptor HY-15403A Atrasentan HY-111343 ONC212
Cholecystokinin Receptor Orexin (OX) Receptor HY-15252 Reparixin HY-10302 MK-3207
Class A Orphans Oxytocin Receptor HY-13443 Exendin-4 HY-10480 Fasiglifam
CRFR P2Y Receptor HY-101978 CPI-444 HY-B0606 Diquafosol
CXCR Platelet-Activating Factor HY-126247 BI-2852 HY-14870 Selexipag
Dopamine Receptor Receptor HY-114436 MRTX-1257 HY-P0171 Motixafortide
EBI2/GPR183 Prolactin-Releasing Peptide HY-13848 AZD8797 HY-14779 Riociguat
Endothelin Receptor Receptor HY-103088 E7046 HY-B0879A Suramin
Formylpeptide Receptor Prostaglandin Receptor HY-14864 Mapracorat HY-114398 BAY-293
GHSR Protease-Activated HY-15894 BQ-788 HY-A0013 Bosentan
Glucocorticoid Receptor Receptor (PAR) HY-19855 AZD-5069 HY-N0583 Hydrocortisone
GNRH Receptor Ras HY-119243 LY2794193 HY-P0082 Glucagon
GPCR19 RGS Protein HY-15319 AMG 487 HY-100775 Setogepram
GPR109A Sigma Receptor HY-50674 INCB3344 HY-10013 Taranabant
GPR119 Somatostatin Receptor HY-12802 AF38469 HY-12080 BX471
GPR120 TSH Receptor HY-101295 Pan-RAS-IN-1 HY-112558 AZ3451
GPR139 Urotensin Receptor HY-19706 ARS-853 HY-16774 Vericiguat
GPR40 Vasopressin Receptor HY-14648 Dexamethasone HY-103193 NKH477
GPR55 Class B: HY-10095 Olcegepant HY-17000 Tolvaptan
GPR84 Glucagon Receptor HY-101980 AZD4635 HY-19904 Adomeglivant
Guanylate Cyclase VIP and PACAP Receptors HY-16168A Degarelix HY-12378 BQ-123
Histamine Receptor HY-P0264 Avexitide HY-B0075 Melatonin
Imidazoline Receptor HY-108677 L-368,899 HY-U00416 ARS-1323
9
MCE
Master of Small Molecules
Neuronal Signaling
5-HT Receptor AChE Cat. No. Product Name Cat. No. Product Name
Adenosine Kinase HY-17366 Clozapine (N-oxide) HY-15084 Dizocilpine (MK-801)
Adrenergic Receptor HY-A0190 Ceruletide (Caerulein) HY-10448 Capsaicin
Amyloid-? Beta-secretase HY-15424 5-Iodotubercidin (NSC 113939) HY-112723 ACT-709478
Calcium Channel HY-32709 Telcagepant (MK-0974) HY-12449 Crenigacestat (LY3039478)
CaMK HY-15608 MPTP HY-15064 HC-030031
Cannabinoid Receptor HY-107422 PAT-1251 HY-12650 Mirogabalin (DS5565)
CGRP Receptor HY-42110 Deschloroclozapine HY-101386 PZM21
Cholecystokinin Receptor HY-14896 Opicapone (BIA 9-1067) HY-18779 PF-4840154
COMT HY-100740 Lanabecestat (AZD3293) HY-10809 Bitopertin (RG1678)
Dopamine Receptor HY-15498 Rimegepant (BMS-927711) HY-B0468 Isoprenaline (Isoproterenol)
Dopamine Transporter HY-12802 AF38469 HY-14773 Mirabegron (YM178)
FAAH GABA Receptor HY-19608 GSK1016790A HY-16567 Asenapine
GlyT GPR119 HY-10095 Olcegepant (BIBN-4096) HY-P0183 Nociceptin (Orphanin FQ)
GPR139 GPR55 HY-50752 LY-411575 HY-P1061A Colivelin
Histamine Receptor HY-19733 Lumateperone (ITI-007) HY-14557A Pimavanserin (ACP-103)
iGluR HY-103040 Zuranolone HY-19654 GSK598809
Imidazoline Receptor HY-P1363 Amyloid ?-Peptide (1-42) HY-106224 Orexin A
mAChR HY-50682 Azeliragon (TTP488) HY-10341 Fasudil (HA-1077)
MCHR1 (GPR24) HY-101736 AMG9810 HY-13526 YO-01027 (Dibenzazepine; DBZ)
Melanocortin Receptor HY-P0128 Amyloid beta-peptide(25-35) HY-12777 Asivatrep (PAC-14028)
Melatonin Receptor HY-10302 MK-3207 HY-15296 Cabergoline (FCE-21336)
mGluR HY-15068 NBQX (FG9202) HY-19370 FPS-ZM1
Monoamine Oxidase HY-12428 A-1165442 HY-13410 Xanomeline (LY246708)
nAChR HY-101507 Pico145 (HC-608) HY-16725 Lemborexant (E-2006)
Neurokinin Receptor HY-19369 L-685458 HY-12882A Ifenprodil
Neuropeptide Y Receptor HY-N2332A Methyllycaconitine citrate HY-19545A SCH 23390
Neurotensin Receptor HY-108337 GNE 0723 HY-15370A SB-269970
Notch HY-B0102A Fluoxetine (LY-110140) HY-P0117 Tat-NR2B9c (NA-1)
Opioid Receptor HY-100714A D-AP5 HY-101299B Dihydrexidine (DAR-0100)
Orexin Receptor (OX Receptor) HY-14176 Compound E HY-P0201 Substance P
Serotonin Transporter HY-B0075 Melatonin HY-17631A Edonerpic (T-817MA)
Sigma Receptor HY-B0726 Pilocarpine HY-14763A Cariprazine (RGH188)
Somatostatin Receptor HY-14280 Entacapone HY-13438 AZD3839
Trk Receptor TRP Channel HY-12745A Nalfurafine (TRK-820) HY-70059 LY341495
?-secretase HY-108690 Fluxametamide HY-16579A Etifoxine
10
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
Membrane Transporter/Ion Channel
ATP Synthase Cat. No. Product Name Cat. No. Product Name
BCRP HY-12750 AZD3965 HY-108337 GNE 0723
Calcium Channel HY-15763 Erastin HY-19778 (R)-BPO-27
CFTR HY-100558 Bafilomycin A1 HY-15699 SAR7334
Chloride Channel HY-100720 GSK2193874 HY-N2143 Fumitremorgin C
CRAC Channel HY-15598 20-HETE HY-112302 HC-070
CRM1 HY-17607 Cenobamate (YKP3089) HY-13017 Ivacaftor (VX-770)
EAAT2 HY-10010 Ko 143 HY-100714A D-AP5
GABA Receptor HY-15409 Empagliflozin (BI 10773) HY-12693 R(+)-IAA-94
GlyT HY-50879 Elacridar (GF120918) HY-101455 CDN1163
HCN Channel HY-111772 Elexacaftor (VX-445) HY-15084 Dizocilpine (MK-801)
iGluR HY-50694 Senicapoc (ICA-17043) HY-10448 Capsaicin
Monoamine Transporter HY-15718A Istaroxime (PST2744) HY-112723 ACT-709478
Monocarboxylate Transporter HY-13248 AR-C155858 HY-12343 ML277 (CID-53347902)
Na+/Ca2+ Exchanger HY-19608 GSK1016790A HY-100965 Diphenyleneiodonium chloride (DPI)
Na+/HCO3- Cotransporter HY-100381 Nigericin HY-15064 HC-030031
Na+/K+ ATPase HY-13433 Thapsigargin HY-12650 Mirogabalin (DS5565)
nAChR HY-100390 (S)-ML753286 HY-50671 Zosuquidar (LY-335979)
NKCC HY-10450 Dapagliflozin (BMS-512148) HY-101840 EIPA (L593754)
P-glycoprotein HY-103040 Zuranolone HY-101664 Ilaprazole (IY-81149)
P2X Receptor HY-15553A Mibefradil (Ro 40-5967) HY-18779 PF-4840154
Potassium Channel HY-101588 Gefapixant (MK-7264) HY-10809 Bitopertin (RG1678)
Proton Pump HY-101736 AMG9810 HY-111651 Gboxin
SGLT HY-10451 Canagliflozin (JNJ 28431754) HY-16738A Eleclazine (GS 6615)
Sodium Channel HY-13434 Ionomycin HY-17384 Valspodar (PSC 833)
TRP Channel HY-101942 CM-4620 HY-12777 Asivatrep (PAC-14028)
URAT1 HY-15068 NBQX (FG9202) HY-12758A YHO-13351
VDAC HY-15640 Capsazepine HY-15258 Lesinurad (RDEA594)
HY-15991 Tenapanor (AZD1722) HY-12882A Ifenprodil
HY-12428 A-1165442 HY-100208 HC-067047
HY-101507 Pico145 (HC-608) HY-14483 AF-353 (Ro-4)
HY-111925 BI-749327 HY-P0117 Tat-NR2B9c (NA-1)
HY-13519 TRAM-34 HY-10634 AMG 517
HY-16589 Oligomycin A (MCH 32) HY-13646 Encequidar (HM30181)
HY-N2332A Methyllycaconitine HY-111325 Synta66
HY-12883 PF 05089771 HY-B1140 Diazoxide (Sch-6783)
11
MCE
Master of Small Molecules
Cytoskeleton
Arp2/3 Complex Cat. No. Product Name Cat. No. Product Name
Dynamin HY-13442A Eribulin Mesylate HY-19792 Mertansine (DM1)
Gap Junction Protein HY-15575 VcMMAE HY-13441 (-)-Blebbistatin
Integrin HY-15162 Monomethyl auristatin E (MMAE) HY-10913A Danegaptide (GAP-134)
Kinesin HY-15584 Taltobulin (HTI-286; SPA-110) HY-16141 Cilengitide (EMD 121974)
Microtubule/Tubulin HY-10222 Ixabepilone (BMS 247550) HY-14951 Firategrast (SB 683699)
Mps1 HY-15578 McMMAF HY-18676 OSU-T315
Myosin HY-B0015 Paclitaxel (Taxol) HY-15102 MK-0429 (L-000845704)
PAK HY-106268A Larazotide HY-N0488 Vincristine (Leurocristine)
HY-15583 Auristatin F HY-50759 Ispinesib (SB-715992)
HY-15204 Tonabersat (SB-220453) HY-12454 DM4
HY-B0011 Docetaxel (RP-56976) HY-P0023 Cyclo(-RGDfK)
HY-15278 Epothilone D (KOS 862) HY-12793 KPT-9274
HY-15886 Mdivi-1 HY-P0122 iRGD peptide (c(CRGDKGPDC))
HY-17029 Epothilone B (Patupilone) HY-13007 PF-3758309
HY-112162 BOS-172722 HY-12858 Empesertib (BAY 1161909)
NF-?B
IKK Cat. No. Product Name Cat. No. Product Name
Keap1-Nrf2 HY-112433 NIK SMI1 HY-112675 4-Octyl Itaconate
MALT1 HY-12212 Omaveloxolone (RTA-408) HY-P0151 SN50
NF-?B HY-18950 GSK2795039 HY-16561 Resveratrol (SRT501)
Reactive Oxygen Species HY-100523 ML385 HY-13060 ACHP (IKK-2 Inhibitor VIII)
HY-15473 MLN120B HY-B0215 Acetylcysteine (NAC)
HY-12213 CDDO-EA (RTA 405) HY-111941 GSK8612
HY-19356 Rocaglamide (Roc-A) HY-12276 MALT1 inhibitor MI-2
HY-100116A Mitoquinone (MitoQ) HY-18935A CBL0137
HY-101140 KI696 HY-115466 MLT-748
HY-13324 Bardoxolone (RTA 402) HY-B1960 Canthaxanthin
HY-13755 Sulforaphane HY-N0005 Curcumin
HY-D0937 Methoxy-PMS HY-13019 BI605906
HY-13453 BAY 11-7082 (BAY 11-7821) HY-14645 (-)-DHMEQ
HY-15725 CDDO-Im (RTA-403; TP-235) HY-13982 JSH-23
HY-D0940 H2DCFDA HY-10514 BX795
12
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
TGF-beta/Smad
PKC Cat. No. Product Name Cat. No. Product Name
ROCK HY-10230 Midostaurin (PKC412) HY-13434 Ionomycin (SQ23377)
TGF-beta/Smad HY-13226 Galunisertib (LY2157299) HY-10343 Sotrastaurin (AEB071)
TGF-? Receptor HY-10431 SB-431542 HY-13012 RepSox (E-616452)
HY-10071 Y-27632 HY-103021 LY3200882
HY-15141 Staurosporine HY-N0439 Asiaticoside
HY-12043 SB 525334 HY-12953 R-268712
HY-15307 SLx-2119 (KD-025) HY-P0118 Disitertide (P144)
HY-15392 Chroman 1 HY-10195B Ruboxistaurin (LY 333531)
HY-12075 LY2109761 HY-15685 Ripasudil (K-115)
HY-13013 (E)-SIS3 HY-13689 Go 6983 (Gö 6983)
HY-B0673 Pirfenidone (AMR69) HY-12659 LX7101
HY-100347A SRI-011381 HY-13521 SB-505124
HY-19928 Vactosertib (TEW-7197) HY-13867 Bisindolylmaleimide I
HY-10432 A 83-01 HY-10342 Enzastaurin (LY317615)
HY-12071 LDN193189 (DM-3189) HY-112782 VTX-27
Vitamin D Related
Vitamin D Cat. No. Product Name
Vitamin D Receptor (VDR) HY-10002 Calcitriol (1,25-Dihydroxyvitamin D3)
HY-A0020 Eldecalcitol (ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3)
HY-32343 Secalciferol ((24R)-24,25-Dihydroxyvitamin D3)
HY-15830 25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol)
HY-10001 Calcipotriol (MC 903; Calcipotriene)
HY-50919 Paricalcitol
HY-76915 24, 25-Dihydroxy VD3
HY-77274 Calcitriol Impurities D
HY-15254 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3
HY-76801 24, 25-Dihydroxy VD2 (24,25-Dihydroxy vitamin D2)
HY-32350 Ercalcitriol (1?,25-Dihydroxy Vitamin D2)
HY-32342 Falecalcitriol
HY-15332 Alfacalcidol-D6
HY-32349 Ercalcidiol (25-hydroxy Vitamin D2)
HY-15157 Calcitetrol (1?, 24, 25-Trihydroxy VD3)
13
MCE
Master of Small Molecules
Antibody-drug Conjugate/ADC Related
The antibody-drug conjugate (ADC) is a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules
(payloads) through chemical linkers. ADCs increase the cell-killing potential of monoclonal antibodies (mAbs), and confer higher tumor selectivity.
Some ADCs has been approved by FDA.
ADC Cytotoxin
Destroys cancer cells
50+
ADC Cytotoxins
Cat. No. Product Name
HY-15162 Monomethyl auristatin E ADC Linker
Joins antibody and drug
HY-15162A D8-MMAE
HY-15584 Taltobulin
HY-15142 Doxorubicin Hydrochloride
HY-13316 Mitomycin C Antibody
Targets cancer cells
HY-19610 alpha-Amanitin
HY-B0015 Paclitaxel
HY-15583 Auristatin F Drug-Linker Conjugates for 500+
HY-16261 Aldoxorubicin ADC ADC Linkers
HY-19609 Calicheamicin Cat. No. Product Name Cat. No. Product Name
HY-19792 Mertansine HY-15575 VcMMAE HY-78738 MC-Val-Cit-PAB
HY-13631D Dxd HY-15578 McMMAF HY-12362 Val-cit-PAB-OH
HY-13062 Daunorubicin Hydrochloride HY-101070 SMCC-DM1 HY-41189 Fmoc-Val-Cit-PAB-PNP
HY-14519 Methotrexate HY-13631E Deruxtecan HY-20336 Mc-Val-Cit-PABC-PNP
HY-13704 SN-38 HY-100374 Val-Cit-PAB-MMAE HY-43869 Vipivotide tetraxetan Linker
HY-15579A MMAF Hydrochloride HY-111012 DBCO-(PEG)3-VC-PAB-MMAE HY-42973 DBCO-NHS ester
HY-16700 PNU-159682 HY-100566 SuO-Val-Cit-PAB-MMAE HY-114430 Fmoc-Phe-Lys(Boc)-PAB-PNP
HY-13061 Daun02 HY-117410 Vipivotide tetraxetan HY-100216 SPDP
HY-15579AS D8-MMAF Hydrochloride HY-126681 SC-VC-PAB-MMAE HY-19318 Fmoc-Val-Cit-PAB
HY-16560 Camptothecin
MedChemExpress
Inhibitors & Agonists
25,000+ Speci?c Inhibitors & Agonists Targeting 20+ Classic Signaling Pathways
Compound Screening Libraries
50+ Compound Screening Libraries Optimized for Disease Mechanism Revealing & Drug Repurposing
Publications Citing Use of MCE Products Nature. 2020 Apr;580(7803):386-390.
Cell. 2020 Apr 6. pii: S0092-8674(20)30268-3.
Cell. 2020 Mar 5;180(5):941-955.e20.
Nature. 2020 Mar;579(7799):433-437.
Science. 2020 Feb 14;367(6479):806-810.
Cell. 2020 Feb 20;180(4):645-654.e13.
Nature. 2019 Dec;576(7786):274-280.
Cell. 2019 Dec 12;179(7):1483-1498.e22.
Cell. 2019 Dec 12;179(7):1566-1581.e16.
Nature. 2019 Nov;575(7782):375-379.
Nature. 2019 Nov;575(7784):683-687.
Nature. 2019 Oct;574(7777):264-267.
Cell. 2019 Oct 31;179(4):864-879.e19.
Nat Nanotechnol. 2019 Oct;14(10):988-993.
Nat Biotechnol. 2019 Oct;37(10):1209-1216.
Cell. 2019 Aug 22;178(5):1145-1158.e20.
Cell. 2019 Aug 22;178(5):1132-1144.e10.
Nature. 2019 Jul;571(7763):127-131.
Science. 2019 Jul 19;365(6450).
Cell. 2019 Jul 25;178(3):585-599.e15.
Cell. 2019 Jul 11;178(2):330-345.e22.
“ Inhibitors & Agonists
We offer 25,000+ selective Inhibitors and Agonists
Targeting 375 key proteins in 20+ signaling pathways
only the Applications in different disease areas
highest-
Screening Libraries
grade MCE Compound Screening Libraries consist of
products! 10,000+ small molecules with
validated biological and pharmacological activities
Quality
Our robust quality control methods assure
product high quality and purity.
Experience
We track the latest scienti?c innovations and
provide you access to the newest compounds.
Validation
Our products biological activities are validated Natur e
Scien ce Ce ll
by worldwide customers and published in the
top scienti?c journals.
Partner
We work together with renowned research
www.MedChemExpress.com institutes and pharmaceutical companies.
Table of Contents Signaling Pathways
PI3K/Akt/mTOR 1
Epigenetics 1
Autophagy 2
Apoptosis 2
Cell Cycle/DNA Damage 3
Metabolic Enzyme/Protease 4
Protein Tyrosine Kinase/RTK 5
Immunology/Inflammation 6
Stem Cell/Wnt 6
Anti-infection 7
JAK/STAT Signaling 8
MAPK/ERK Pathway 8
GPCR/G Protein 9
Neuronal Signaling 10
Membrane Transporter/Ion Channel 11
Cytoskeleton 12
NF-?B 12
TGF-beta/Smad 13
VD/VDR 13
Antibody-drug Conjugate/ADC Related 14
PROTAC 15
Compound Screening Libraries 16
Virtual Screening 19
Dye Reagents 22
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
PI3K/Akt/mTOR
Akt AMPK Cat. No. Product Name Cat. No. Product Name
ATM/ATR DNA-PK HY-10219 Rapamycin (Sirolimus) HY-13003 Torin 1
GSK-3 MELK HY-15244 Alpelisib HY-15186 Ipatasertib (GDC-0068; RG7440)
mTOR PDK-1 HY-19312 3-Methyladenine (3-MA) HY-13522 Fimepinostat (CUDC-907)
PI3K PI4K HY-10182 CHIR-99021 HY-70063 Buparlisib (BKM120)
PIKfyve PTEN HY-10108 LY294002 HY-13002 Torin 2
HY-10358 MK-2206 HY-13417 AICAR
HY-19323 Ceralasertib (AZD6738) HY-101566A BAY-1895344
HY-12513 LY3023414 HY-P0175 740 Y-P
HY-10218 Everolimus (RAD001) HY-10422 AZD-8055
HY-101562 GDC-0077 HY-13026 Idelalisib (CAL-101; GS-1101)
HY-101570 Nedisertib HY-19939S VX-984
HY-15346 Copanlisib HY-10514 BX795
HY-13902 Berzosertib (VE-822; VX-970) HY-15512A OTSSP167
HY-15431 Capivasertib (AZD5363) HY-13074 VO-Ohpic
HY-17471A Metformin HY-12046 PIK-93
Epigenetics
AMPK Cat. No. Product Name Cat. No. Product Name
Aurora Kinase HY-13030 (+)-JQ-1 HY-15149 Romidepsin (FK 228)
DNA Methyltransferase HY-15743 Birabresib (OTX-015; MK-8628) HY-15145 SRT 1720
Epigenetic Reader Domain HY-13803 Tazemetostat (EPZ-6438) HY-12635 SP2509
HDAC HY-13470 GSK126 HY-108696 GNE-781
Histone Acetyltransferase HY-107455 A-485 HY-A0004 Decitabine (5-Aza-2'-deoxycytidine)
Histone Demethylase HY-104048 QC6352 HY-13980 UNC0642
Histone Methyltransferase HY-101563 GSK3326595 HY-15452 Selisistat (EX-527)
JAK HY-15144 Trichostatin A (TSA) HY-111048 Corin
MicroRNA HY-15229 Guadecitabine (SGI-110) HY-13235 I-BET151
PARP HY-13032 Molibresib (I-BET762; GSK525762) HY-100482 CPI-637
PKC HY-103713 Seclidemstat (SP-2577) HY-12186 3-Deazaneplanocin A (DZNep)
Protein Arginine Deiminase HY-13418 Dorsomorphin (Compound C) HY-100514 GSK484
Sirtuin HY-15648B GSK-J4 HY-16425 RG2833
HY-101564 JNJ-64619178 HY-12163 Entinostat (MS-275)
HY-16925 MI-503 HY-10224 Panobinostat (LBH589)
1
MCE
Master of Small Molecules
Autophagy
Autophagy FKBP Cat. No. Product Name Cat. No. Product Name
LRRK2 Mitophagy HY-11109 Resatorvid (TAK-242) HY-10971 Alisertib (MLN8237?
ULK HY-10162 Olaparib (AZD2281) HY-B0015 Paclitaxel (Taxol)
HY-100411 MLi-2 HY-17559 Actinomycin D
HY-70002 Enzalutamide (MDV3100) HY-17394 Cisplatin (CDDP)
HY-B0146 Verteporfin HY-15371 Forskolin (Coleonol)
HY-13756 Tacrolimus (FK506; Fujimycin) HY-17371 Oxaliplatin
HY-13992 AP20187 HY-13636 Fulvestrant (ICI 182780)
HY-13259 MG-132 HY-12481 SAR405
HY-19312 3-Methyladenine (3-MA) HY-100006A MRT68921
HY-13251 Silvestrol HY-16966 SBI-0206965
HY-12320 Cycloheximide (Actidione; CHX) HY-13018 MRT67307
HY-10108 LY294002 HY-100941 CCCP
HY-15142 Doxorubicin HY-16592 Brefeldin A (BFA)
HY-100558 Bafilomycin A1 HY-12990 Spautin-1
HY-50856 Ruxolitinib (INCB18424) HY-10129 Veliparib (ABT-888)
Apoptosis
Apoptosis Bcl-2 Family Cat. No. Product Name Cat. No. Product Name
c-Myc Caspase HY-100741 S63845 HY-100579 Ferrostatin-1
DAPK Ferroptosis HY-10087 Navitoclax (ABT-263) HY-16046 Rimiducid (AP1903)
FKBP IAP HY-13756 Tacrolimus (FK506; Fujimycin) HY-F0003 NADPH
MDM-2/p53 PKD HY-13992 AP20187 (B/B Homodimerizer) HY-101565 AMG-176
RIP Kinase Survivin HY-16658 Z-VAD(OMe)-FMK HY-101297 Z-IETD-FMK
Thymidylate Synthase HY-15763 Erastin HY-18658 Siremadlin (HDM 201)
TNF Receptor HY-13205 Belnacasan (VX-765) HY-19741 A-1331852
HY-15676 Idasanutlin (RG7388) HY-12466 Z-DEVD-FMK
HY-114481 Imidazole ketone erastin (IKE) HY-102080 SAFit2
HY-12296 AMG 232 HY-12726 Liproxstatin-1
HY-50936 Trabectedin (ET-743) HY-12635 SP2509
HY-15531 Venetoclax (ABT-199; GDC-0199) HY-13002 Torin 2
HY-12305 Q-VD-OPh (QVD-OPH? HY-50907 ABT-737
HY-15518 LCL161 HY-16591 Birinapant
HY-10959 RG7112 HY-10396 Emricasan (PF 03491390)
2
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
Cell Cycle/DNA Damage
Antifolate Cat. No. Product Name Cat. No. Product Name
APC HY-13631A Exatecan HY-16592 Brefeldin A (BFA)
ATM/ATR HY-13442A Eribulin Mesylate HY-12137 Volasertib (BI 6727)
Aurora Kinase HY-10162 Olaparib (AZD2281) HY-16209 Forodesine (BCX-1777)
Casein Kinase HY-10619 Niraparib (MK-4827) HY-101212 CYC065
CDK HY-114177 PF-06873600 HY-103618 THZ531
Checkpoint Kinase (Chk) HY-16737 Elafibranor (GFT505) HY-13624A Epirubicin (4'-Epidoxorubicin)
CRISPR/Cas9 HY-15162 Monomethyl auristatin E (MMAE) HY-50855 Silmitasertib (CX-4945)
Deubiquitinase HY-13251 Silvestrol HY-50935 Troglitazone (CS-045)
DNA Alkylator/Crosslinker HY-12320 Cycloheximide (Actidione; CHX) HY-17371 Oxaliplatin
DNA-PK HY-16297 Abemaciclib (LY2835219) HY-104044 Pamiparib (BGB-290)
DNA/RNA Synthesis HY-10993 Adavosertib (AZD1775; MK-1775) HY-16261 Aldoxorubicin (INNO-206)
Eukaryotic Initiation Factor (eIF) HY-10617 Rucaparib (AG-014699) HY-80013 THZ1
G-quadruplex HY-50767 Palbociclib (PD 0332991) HY-101566A BAY-1895344
Haspin Kinase HY-13316 Mitomycin C (Ametycine) HY-112162 BOS-172722
HDAC HY-19323 Ceralasertib (AZD6738) HY-10129 Veliparib (ABT-888)
HSP HY-103712A Samuraciclib (CT7001) HY-12214A NVP-2
IRE1 HY-112088 AZD4573 HY-13469 Debio 0932 (CUDC-305)
Kinesin HY-16106 Talazoparib (BMN-673) HY-19831 4EGI-1
LIM Kinase (LIMK) HY-17565 Bleomycin HY-13753 Streptozocin (Streptozotocin)
Microtubule/Tubulin HY-112654 GCN2iB HY-B0779 Teprenone (Geranylgeranylacetone)
Mps1 HY-10971 Alisertib (MLN 8237) HY-12871B Atuveciclib (BAY-1143572)
Nucleoside Antimetabolite/Analog HY-12037 Rigosertib (ON-01910) HY-15372 GW 6471
p97 HY-B0015 Paclitaxel (Taxol) HY-114258 LY3295668 (AK-01)
PAK HY-17559 Actinomycin D HY-90006 5-Fluorouracil (5-FU)
PARP HY-104040 MKC8866 HY-30237 Seliciclib (Roscovitine; CYC202)
PERK HY-19620 Branaplam (LMI070) HY-15725 CDDO-Im (RTA-403)
Polo-like Kinase (PLK) HY-17394 Cisplatin (CDDP) HY-100888 Simurosertib (TAK-931)
PPAR HY-101570 Nedisertib (M3814) HY-18682 Centrinone (LCR-263)
RAD51 HY-10211 Tanespimycin (17-AAG) HY-18072 GSK2606414
ROCK HY-13902 Berzosertib (VE-822; VX-970) HY-17618 Pemafibrate
Sirtuin HY-15777 Ribociclib (LEE011) HY-107986 GNE-6776
SRPK HY-109101 Risdiplam (RG7916; RO7034067) HY-12861 CB-5083
Telomerase HY-18174 Prexasertib (LY2606368) HY-130250 SR-4835
TOPK HY-17364 Temozolomide (TMZ) HY-15147 XAV-939
Topoisomerase HY-10492 Dinaciclib (SCH 727965) HY-13323 CX-5461
3
MCE
Master of Small Molecules
Metabolic Enzyme/Protease
Oxidoreductases: Elastase Cat. No. Product Name Cat. No. Product Name
5 alpha Reductase Factor Xa HY-12248 Telaglenastat HY-10227 Bortezomib
5'-Deiodinase Glucosidase HY-12222 Obeticholic acid HY-N0565B Doxycycline
Aldehyde Dehydrogenase MAGL HY-16901 Firsocostat HY-101560 Linrodostat
Aldose Reductase MMP HY-13756 Tacrolimus HY-14434 Asunaprevir
Cytochrome P450 Neprilysin HY-70062 Pevonedistat HY-15193 EMD638683
Dopamine ?-hydroxylase Phosphatase HY-13259 MG-132 HY-P0025 NIM811
Glutathione Peroxidase Phosphodiesterase (PDE) HY-19312 3-Methyladenine HY-B0764 Bucladesine
HIF/HIF Prolyl-Hydroxylase Phospholipase HY-12219A MSI-1436 HY-100116A Mitoquinone
HMG-CoA Reductase Proteasome HY-15689 Epacadostat HY-13426 Roxadustat
Indoleamine 2,3-Dioxygenase Renin HY-12867 PT-2385 HY-120384 AZD-0284
Isocitrate Dehydrogenase Soluble Epoxide Hydrolase HY-109083 Cilofexor HY-50876 (E)-Daporinad
Lactate Dehydrogenase Thrombin HY-18657 TEPP-46 HY-112929 DT-061
Lipoxygenase Lyases: HY-116009 RMC-4550 HY-108697 PT2399
NADPH Oxidase Carbonic Anhydrase HY-101979A CB-1158 HY-50108 GW 4064
Stearoyl-CoA Desaturase Decarboxylase HY-15424 5-Iodotubercidin HY-17367A Atazanavir
Tryptophan Hydroxylase Enolase HY-107418 Tropifexor HY-17605 Bictegravir
Tyrosinase Ligase: HY-12434 INT-767 HY-13966 2-Deoxy-D-glucose
Xanthine Oxidase Acetyl-CoA Carboxylase HY-15676 Idasanutlin HY-D0937 Methoxy-PMS
Transferases: Isomerase HY-12296 AMG 232 HY-18767 Ivosidenib
COMT Others: HY-100388 SHP099 HY-14771A Imeglimin
Acyltransferase CETP HY-18770B Navoximod HY-10502 Tipifarnib
Carbohydrate transferase Drug Metabolite HY-112645 BAY-2402234 HY-15287A Nelfinavir
E1/E2/E3 Enzyme Endogenous Metabolite HY-101842 ND-646 HY-13469 Debio 0932
Farnesyl Transferase FXR HY-104037 Cintirorgon HY-10912 Fexaramine
Fatty Acid Synthase (FAS) HCV Protease HY-101772 Ziritaxestat HY-14992 Bay 60-7550
Gutathione S-transferase HIV Integrase HY-18950 GSK2795039 HY-B0779 Teprenone
Nampt HIV Protease HY-15371 Forskolin HY-15768 Ilomastat
Pyruvate Kinase LXR HY-16278 Pradigastat HY-104042 Vorasidenib
Hydrolases: Mineralocorticoid Receptor HY-100218A RSL3 HY-15760 Necrostatin-1
Ester hydrolase Mitochondrial Metabolism HY-12270 T-5224 HY-109011 Rosiptor
Adenosine Deaminase RAR/RXR HY-B0763 Ibudilast HY-15148 Tipranavir
Aminopeptidase Reactive Oxygen Species HY-125840 PT2977 HY-13233A Talabostat
ACE ROR HY-100337 WWL70 HY-100742A (R)-GNE-140
Cathepsin Ser/Thr Protease HY-14896 Opicapone HY-100487 TAK-243
Dipeptidyl Peptidase HY-122218 JHU-083 HY-10231 PX-478
4
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
Protein Tyrosine Kinase/RTK
Receptor Tyrosine Kinases Cat. No. Product Name Cat. No. Product Name
(RTKs): HY-16749 Pexidartinib (PLX-3397) HY-12050 CP-673451
ALK HY-112301 Pralsetinib (BLU-667) HY-12289 Defactinib (VS-6063)
c-Fms HY-P9907 Trastuzumab HY-18007 ALW-II-41-27
c-Kit HY-10997 Ibrutinib (PCI-32765) HY-100492 Fisogatinib (BLU-554)
c-Met/HGFR HY-114153 PLX5622 HY-101474A Zanubrutinib (BGB-3111)
Discoidin Domain Receptor HY-12768 BLZ945 HY-10181 Dasatinib (BMS-354825)
EGFR HY-109078 Vecabrutinib (SNS-062) HY-13342 Apatinib (YN968D1)
Ephrin Receptor HY-15150 Bemcentinib (R428; BGB324) HY-101916 Heparan
FGFR HY-16961 Sitravatinib (MGCD516) HY-129550 BI-4020
FLT3 HY-15772 Osimertinib (AZD-9291) HY-13024 Rebastinib (DCC-2036)
IGF-1R HY-P9905 Cetuximab (C225) HY-13016 Cabozantinib (XL184)
Insulin Receptor HY-P9906 Bevacizumab HY-10261 Afatinib (BIBW 2992)
PDGFR HY-10374 Semaxinib (SU5416) HY-15730 Poziotinib (HM781-36B)
RET HY-112306 Ripretinib (DCC-2618) HY-50895 Gefitinib (ZD1839)
ROS HY-10981 Lenvatinib (E7080) HY-10191 Linsitinib (OSI-906)
TAM Receptor HY-50904 Nintedanib (BIBF 1120) HY-13001 Quizartinib (AC220)
Trk Receptor HY-112299 TAS6417 HY-12823 BLU9931
VEGFR HY-109099 Pemigatinib (INCB054828) HY-101568 Roblitinib (FGF-401)
HY-18708 Erdafitinib (JNJ-42756493) HY-12866A Larotrectinib (LOXO-101)
HY-17600 Acalabrutinib (ACP-196) HY-112215 ARQ 531
Non-Receptor Tyrosine Kinases HY-P9912 Pertuzumab HY-13223 Crenolanib (CP-868596)
(NRTKs): HY-12432 Gilteritinib (ASP2215) HY-101549 MRX-2843 (UNC2371)
Ack1 HY-18750 AZD3759 HY-128757 Remibrutinib
Bcr-Abl HY-101977 Selitrectinib (LOXO-195) HY-15514A Merestinib (LY2801653)
BMX Kinase HY-100818 Futibatinib (TAS-120) HY-15458 SAR131675
Btk HY-13311 Infigratinib (BGJ-398) HY-15959 Savolitinib (Volitinib; AZD-6094)
FAK HY-114370 Selpercatinib (LOXO-292) HY-11092 BMS-509744
Itk HY-101561 Avapritinib (BLU-285) HY-109086 Edicotinib (JNJ-40346527)
Pyk2 HY-P0035 Insulin (human) HY-103022 Repotrectinib (TPX-0005)
Src HY-100342 Ibrutinib-biotin HY-10200 BMS-754807
Syk HY-104065 Pyrotinib (SHR-1258) HY-12857 Brigatinib (AP-26113)
HY-16069 Tucatinib (Irbinitinib; ONT-380) HY-50878 Crizotinib (PF-02341066)
HY-12215 Lorlatinib (PF-06463922) HY-19834 Fenebrutinib (GDC-0853)
HY-10331 Regorafenib (BAY 73-4506) HY-15764A A 419259 (RK 20449)
HY-100867A TAK-659 HY-101215 Evobrutinib (M2951)
5
MCE
Master of Small Molecules
Immunology/Inflammation
Aryl Hydrocarbon Receptor Cat. No. Product Name Cat. No. Product Name
CCR CD73 HY-12885B ADU-S100 (MIW815) HY-10218 Everolimus (RAD001)
Complement System HY-10037 Quiflapon (MK591) HY-15776 HG-9-91-01
COX CXCR HY-117287 BMS-986165 HY-101147 YKL-05-099
FKBP FLAP HY-11109 Resatorvid (TAK-242) HY-16046 Rimiducid (AP1903)
Galectin IFNAR HY-14882A Cenicriviroc (TAK-652) HY-17589 Chloroquine Phosphate
Interleukin Related HY-13756 Tacrolimus (FK506; Fujimycin) HY-B0579 Cyclosporin A (Cyclosporine)
IRAK MyD88 HY-12815A MCC950 (CP-456773; CRID3) HY-17627 Avacopan (CCX168)
NO Synthase HY-13992 AP20187 HY-108730 Avelumab
NOD-like Receptor (NLR) HY-P9904 Atezolizumab HY-102080 SAFit2
PD-1/PD-L1 PGE Synthase HY-18739 Phorbol 12-myristate 13-acetate HY-109044 Tapinarof (GSK2894512)
Reactive Oxygen Species HY-50937 ST 2825 HY-13740 Resiquimod (R848)
Salt-inducible Kinase (SIK) HY-112921B diABZI STING agonist-1 HY-109104 Telratolimod (MEDI 9197; 3M-052)
SPHK STING HY-10964 Vadimezan (DMXAA; ASA-404) HY-100116A Mitoquinone
Thrombopoietin Receptor HY-13245 PF-4136309 (INCB8761) HY-50674 INCB3344
Toll-like Receptor (TLR) HY-19745 BMS-202 HY-P9903 Nivolumab (BMS-936558)
Stem Cell/Wnt
Casein Kinase ERK Cat. No. Product Name Cat. No. Product Name
Gli GSK-3 HY-B0146 Verteporfin (CL 318952) HY-15147 XAV-939
Hedgehog Hippo (MST) HY-10182 CHIR-99021 (CT99021) HY-12681 CCT251545
JAK Notch HY-10071 Y-27632 HY-13418A Dorsomorphin (Compound C)
Oct3/4 PKA HY-16975 SH-4-54 HY-109049 Adavivint (SM04690)
Porcupine ROCK HY-50846 SCH772984 HY-19369 L-685458
sFRP-1 Smo HY-17545 LGK974 (WNT974) HY-116830 BRD0705
STAT TGF-beta/Smad HY-100526 XMU-MP-1 HY-13257 Thiazovivin
Wnt YAP HY-15307 SLx-2119 (KD-025) HY-11102 RO4929097 (RG-4733)
?-catenin ?-secretase HY-15392 Chroman 1 HY-14176 Compound E
HY-13027 DAPT (GSI-IX) HY-10590 TWS119
HY-14428 ICG-001 HY-16294 LY2090314
HY-50752 LY-411575 HY-14443 XMD8-92
HY-17024 Cyclopamine (11-Deoxojervine) HY-100830 NCB-0846
HY-15185 Nirogacestat (PF-3084014) HY-15659 Wnt-C59 (C59)
HY-13901 GANT 61 (NSC 136476) HY-10046 Plerixafor (AMD 3100)
6
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
Anti-infection
Arenavirus Bacterial Cat. No. Product Name Cat. No. Product Name
CMV Enterovirus HY-104077 Remdesivir (GS-5734) HY-17362 Vancomycin
Filovirus Fungal HY-14882A Cenicriviroc (TAK-652) HY-B0490 Hygromycin B
HBV HCV HY-19930 Vaborbactam (RPX7009) HY-15148 Tipranavir (PNU-140690)
HIV HSV HY-109025 Baloxavir marboxil (S-033188) HY-13986 Merimepodib (VX-497)
Influenza Virus Parasite HY-12320 Cycloheximide (Actidione; CHX) HY-12983 ALS-8112
Reverse Transcriptase HY-17628 Cefiderocol (S-649266) HY-17409 Nystatin
RSV SARS-CoV HY-17565 Bleomycin HY-15303 Pritelivir (BAY 57-1293; AIC316)
Virus Protease HY-15695 Puromycin Aminonucleoside HY-10846 Delamanid (OPC-67683)
HY-18649 Galidesivir (BCX4430) HY-16727 Presatovir (GS-5806)
HY-50101A Mavorixafor (AMD-070 ) HY-10241 Simeprevir (TMC435)
HY-17006 Caspofungin Acetate (MK- 0991) HY-17586 Dalbavancin (BI-397)
HY-B1743A Puromycin (CL13900) HY-15597 Salinomycin (Procoxacin)
HY-17589 Chloroquine HY-14989 SQ109 (NSC722041)
HY-A0098 Tunicamycin HY-13004 Maraviroc (UK-427857)
HY-12594 Paritaprevir (ABT-450) HY-14768 Favipiravir (T-705)
HY-14865C Omadacycline (PTK0796) HY-13238 Dolutegravir (S/GSK1349572)
HY-N0565B Doxycycline HY-112205A RR-11a analog
HY-14434 Asunaprevir (BMS-650032) HY-10493 Cobicistat (GS-9350)
HY-12559 Alisporivir (Debio-025) HY-B0117 Tigecycline (GAR-936)
HY-P0025 NIM811 HY-101954 Inarigivir
HY-13740 Resiquimod (R848) HY-16468 Squalamine (MSI-1256)
HY-16742 Gepotidacin (GSK2140944) HY-15460 CHIR-090
HY-100029 Bay 41-4109 HY-90001 Ritonavir (ABT 538)
HY-14879A Avibactam (NXL-104) HY-15233 Letermovir (AIC246)
HY-104012 Islatravir (MK-8591) HY-B0522A Ampicillin
HY-13318 Oseltamivir acid (GS 4071) HY-16973 Fluralaner (A1443)
HY-14737 Ceftaroline fosamil (TAK-599) HY-101479 Iclaprim (AR-100)
HY-17367A Atazanavir (BMS-232632) HY-10373 Trimetrexate (CI-898)
HY-17605 Bictegravir (GS-9883) HY-B1123 Auranofin (SKF-39162)
HY-15287A Nelfinavir (AG-1343) HY-16980A Eravacycline (TP-434)
HY-17561 G-418 (Geneticin) HY-15298 Grazoprevir (MK-5172)
HY-16752 Relebactam (MK-7655) HY-135747 Gut restricted-7
HY-112579 Ceftobiprole (Ro 63-9141) HY-P0017 Aprotinin
HY-14881 Bedaquiline (TMC207) HY-10392 Sutezolid (PNU-100480)
HY-16730 Sarolaner (PF-6450567) HY-17593 Solithromycin (CEM-101)
7
MCE
Master of Small Molecules
JAK/STAT Signaling
EGFR JAK Cat. No. Product Name Cat. No. Product Name
Pim STAT HY-19322B PIM-447 (LGH447) HY-104065 Pyrotinib (SHR-1258)
HY-117287 BMS-986165 HY-16069 Tucatinib (Irbinitinib)
HY-P9907 Trastuzumab HY-129550 BI-4020
HY-109053 Delgocitinib (JTE-052) HY-10261 Afatinib (BIBW 2992)
HY-19569 Upadacitinib (ABT-494) HY-15730 Poziotinib (HM781-36B)
HY-15772 Osimertinib (AZD-9291) HY-50895 Gefitinib (ZD1839)
HY-P9905 Cetuximab (C225) HY-100754 PF-06651600
HY-50856 Ruxolitinib (INCB18424) HY-10409 Fedratinib (TG-101348)
HY-16975 SH-4-54 HY-16997 Itacitinib (INCB039110)
HY-112299 TAS6417 HY-50896 Erlotinib (CP-358774)
HY-P9912 Pertuzumab HY-15146 NSC 74859 (S3I-201)
HY-18750 AZD3759 HY-100494 SH5-07
HY-104065B Pyrotinib (SHR-1258) HY-13050 Sapitinib (AZD-8931)
HY-40354 Tofacitinib (CP-690550) HY-16379 Pacritinib (SB1518)
HY-18960 CHZ868 HY-111553 TAS0728
MAPK/ERK Pathway
ERK Cat. No. Product Name Cat. No. Product Name
JNK HY-15605 Encorafenib (LGX818) HY-18972 PLX8394
KLF HY-50846 SCH772984 HY-50706 Selumetinib (AZD6244)
MAP3K HY-10256 SB 203580 HY-10999A Trametinib (GSK-1120212)
MAP4K HY-100022 Tomivosertib (eFT508) HY-14660 Dabrafenib (GSK2118436)
MAPKAPK2 (MK2) HY-12057 Vemurafenib (PLX4032) HY-10254 PD0325901
MEK HY-18938 Selonsertib (GS-4997) HY-10402 Losmapimod (GW856553X)
Mixed Lineage Kinase HY-12028 PD98059 HY-15202 Binimetinib (MEK162)
MNK HY-12031 U0126 HY-12599 URMC-099
p38 MAPK HY-13064 Cobimetinib (GDC-0973) HY-12558 LY3009120 (DP-4978)
Raf HY-10201 Sorafenib (Bay 43-9006) HY-10295 SB 202190
Ribosomal S6 Kinase (RSK) HY-32018 Cot inhibitor-2 HY-12947 GNE-3511
HY-15947 Ravoxertinib (GDC-0994) HY-15816 Ulixertinib (BVD-523)
HY-112082 BAY885 HY-103490 Takinib
HY-10999 Trametinib (GSK1120212) HY-52101 CMK
HY-112089 LXH254 HY-10510 BI-D1870
8
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
GPCR/G Protein
Class A: Kisspeptin Receptor Cat. No. Product Name Cat. No. Product Name
Adenosine Receptor Leukotriene Receptor HY-114277 AMG-510 HY-15778 AVE 0991
Adenylate Cyclase LPL Receptor HY-U00418 ARS-1620 HY-15418 RS 504393
Adiponectin Receptor mAChR HY-15677 INT-777 HY-19870 Setmelanotide
Adrenergic Receptor MCHR1 (GPR24) HY-130149 MRTX849 HY-13951 ICI 118,551
Adrenergic Receptor Melanocortin Receptor HY-112185 GLP-1 receptor agonist 1 HY-12355 Siponimod
Angiotensin Receptor Melatonin Receptor HY-12434 INT-767 HY-15848 AdipoRon
Apelin Receptor mGluR HY-13948 Angiotensin II human HY-10017 SCH 546738
Bombesin Receptor Motilin Receptor HY-P0014 Liraglutide HY-P0202 Endothelin 1
Bradykinin Receptor Neurokinin Receptor HY-13245 PF-4136309 HY-101952 Prostaglandin E2
Cannabinoid Receptor Neuromedin U receptor 2 HY-32709 Telcagepant HY-100619 BMS-986020
CaSR Neuropeptide Y Receptor HY-15608 MPTP HY-10198 Navarixin
CCR Neurotensin Receptor HY-50101A Mavorixafor HY-114118A Semaglutide
CGRP Receptor Opioid Receptor HY-15403A Atrasentan HY-111343 ONC212
Cholecystokinin Receptor Orexin (OX) Receptor HY-15252 Reparixin HY-10302 MK-3207
Class A Orphans Oxytocin Receptor HY-13443 Exendin-4 HY-10480 Fasiglifam
CRFR P2Y Receptor HY-101978 CPI-444 HY-B0606 Diquafosol
CXCR Platelet-Activating Factor HY-126247 BI-2852 HY-14870 Selexipag
Dopamine Receptor Receptor HY-114436 MRTX-1257 HY-P0171 Motixafortide
EBI2/GPR183 Prolactin-Releasing Peptide HY-13848 AZD8797 HY-14779 Riociguat
Endothelin Receptor Receptor HY-103088 E7046 HY-B0879A Suramin
Formylpeptide Receptor Prostaglandin Receptor HY-14864 Mapracorat HY-114398 BAY-293
GHSR Protease-Activated HY-15894 BQ-788 HY-A0013 Bosentan
Glucocorticoid Receptor Receptor (PAR) HY-19855 AZD-5069 HY-N0583 Hydrocortisone
GNRH Receptor Ras HY-119243 LY2794193 HY-P0082 Glucagon
GPCR19 RGS Protein HY-15319 AMG 487 HY-100775 Setogepram
GPR109A Sigma Receptor HY-50674 INCB3344 HY-10013 Taranabant
GPR119 Somatostatin Receptor HY-12802 AF38469 HY-12080 BX471
GPR120 TSH Receptor HY-101295 Pan-RAS-IN-1 HY-112558 AZ3451
GPR139 Urotensin Receptor HY-19706 ARS-853 HY-16774 Vericiguat
GPR40 Vasopressin Receptor HY-14648 Dexamethasone HY-103193 NKH477
GPR55 Class B: HY-10095 Olcegepant HY-17000 Tolvaptan
GPR84 Glucagon Receptor HY-101980 AZD4635 HY-19904 Adomeglivant
Guanylate Cyclase VIP and PACAP Receptors HY-16168A Degarelix HY-12378 BQ-123
Histamine Receptor HY-P0264 Avexitide HY-B0075 Melatonin
Imidazoline Receptor HY-108677 L-368,899 HY-U00416 ARS-1323
9
MCE
Master of Small Molecules
Neuronal Signaling
5-HT Receptor AChE Cat. No. Product Name Cat. No. Product Name
Adenosine Kinase HY-17366 Clozapine (N-oxide) HY-15084 Dizocilpine (MK-801)
Adrenergic Receptor HY-A0190 Ceruletide (Caerulein) HY-10448 Capsaicin
Amyloid-? Beta-secretase HY-15424 5-Iodotubercidin (NSC 113939) HY-112723 ACT-709478
Calcium Channel HY-32709 Telcagepant (MK-0974) HY-12449 Crenigacestat (LY3039478)
CaMK HY-15608 MPTP HY-15064 HC-030031
Cannabinoid Receptor HY-107422 PAT-1251 HY-12650 Mirogabalin (DS5565)
CGRP Receptor HY-42110 Deschloroclozapine HY-101386 PZM21
Cholecystokinin Receptor HY-14896 Opicapone (BIA 9-1067) HY-18779 PF-4840154
COMT HY-100740 Lanabecestat (AZD3293) HY-10809 Bitopertin (RG1678)
Dopamine Receptor HY-15498 Rimegepant (BMS-927711) HY-B0468 Isoprenaline (Isoproterenol)
Dopamine Transporter HY-12802 AF38469 HY-14773 Mirabegron (YM178)
FAAH GABA Receptor HY-19608 GSK1016790A HY-16567 Asenapine
GlyT GPR119 HY-10095 Olcegepant (BIBN-4096) HY-P0183 Nociceptin (Orphanin FQ)
GPR139 GPR55 HY-50752 LY-411575 HY-P1061A Colivelin
Histamine Receptor HY-19733 Lumateperone (ITI-007) HY-14557A Pimavanserin (ACP-103)
iGluR HY-103040 Zuranolone HY-19654 GSK598809
Imidazoline Receptor HY-P1363 Amyloid ?-Peptide (1-42) HY-106224 Orexin A
mAChR HY-50682 Azeliragon (TTP488) HY-10341 Fasudil (HA-1077)
MCHR1 (GPR24) HY-101736 AMG9810 HY-13526 YO-01027 (Dibenzazepine; DBZ)
Melanocortin Receptor HY-P0128 Amyloid beta-peptide(25-35) HY-12777 Asivatrep (PAC-14028)
Melatonin Receptor HY-10302 MK-3207 HY-15296 Cabergoline (FCE-21336)
mGluR HY-15068 NBQX (FG9202) HY-19370 FPS-ZM1
Monoamine Oxidase HY-12428 A-1165442 HY-13410 Xanomeline (LY246708)
nAChR HY-101507 Pico145 (HC-608) HY-16725 Lemborexant (E-2006)
Neurokinin Receptor HY-19369 L-685458 HY-12882A Ifenprodil
Neuropeptide Y Receptor HY-N2332A Methyllycaconitine citrate HY-19545A SCH 23390
Neurotensin Receptor HY-108337 GNE 0723 HY-15370A SB-269970
Notch HY-B0102A Fluoxetine (LY-110140) HY-P0117 Tat-NR2B9c (NA-1)
Opioid Receptor HY-100714A D-AP5 HY-101299B Dihydrexidine (DAR-0100)
Orexin Receptor (OX Receptor) HY-14176 Compound E HY-P0201 Substance P
Serotonin Transporter HY-B0075 Melatonin HY-17631A Edonerpic (T-817MA)
Sigma Receptor HY-B0726 Pilocarpine HY-14763A Cariprazine (RGH188)
Somatostatin Receptor HY-14280 Entacapone HY-13438 AZD3839
Trk Receptor TRP Channel HY-12745A Nalfurafine (TRK-820) HY-70059 LY341495
?-secretase HY-108690 Fluxametamide HY-16579A Etifoxine
10
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
Membrane Transporter/Ion Channel
ATP Synthase Cat. No. Product Name Cat. No. Product Name
BCRP HY-12750 AZD3965 HY-108337 GNE 0723
Calcium Channel HY-15763 Erastin HY-19778 (R)-BPO-27
CFTR HY-100558 Bafilomycin A1 HY-15699 SAR7334
Chloride Channel HY-100720 GSK2193874 HY-N2143 Fumitremorgin C
CRAC Channel HY-15598 20-HETE HY-112302 HC-070
CRM1 HY-17607 Cenobamate (YKP3089) HY-13017 Ivacaftor (VX-770)
EAAT2 HY-10010 Ko 143 HY-100714A D-AP5
GABA Receptor HY-15409 Empagliflozin (BI 10773) HY-12693 R(+)-IAA-94
GlyT HY-50879 Elacridar (GF120918) HY-101455 CDN1163
HCN Channel HY-111772 Elexacaftor (VX-445) HY-15084 Dizocilpine (MK-801)
iGluR HY-50694 Senicapoc (ICA-17043) HY-10448 Capsaicin
Monoamine Transporter HY-15718A Istaroxime (PST2744) HY-112723 ACT-709478
Monocarboxylate Transporter HY-13248 AR-C155858 HY-12343 ML277 (CID-53347902)
Na+/Ca2+ Exchanger HY-19608 GSK1016790A HY-100965 Diphenyleneiodonium chloride (DPI)
Na+/HCO3- Cotransporter HY-100381 Nigericin HY-15064 HC-030031
Na+/K+ ATPase HY-13433 Thapsigargin HY-12650 Mirogabalin (DS5565)
nAChR HY-100390 (S)-ML753286 HY-50671 Zosuquidar (LY-335979)
NKCC HY-10450 Dapagliflozin (BMS-512148) HY-101840 EIPA (L593754)
P-glycoprotein HY-103040 Zuranolone HY-101664 Ilaprazole (IY-81149)
P2X Receptor HY-15553A Mibefradil (Ro 40-5967) HY-18779 PF-4840154
Potassium Channel HY-101588 Gefapixant (MK-7264) HY-10809 Bitopertin (RG1678)
Proton Pump HY-101736 AMG9810 HY-111651 Gboxin
SGLT HY-10451 Canagliflozin (JNJ 28431754) HY-16738A Eleclazine (GS 6615)
Sodium Channel HY-13434 Ionomycin HY-17384 Valspodar (PSC 833)
TRP Channel HY-101942 CM-4620 HY-12777 Asivatrep (PAC-14028)
URAT1 HY-15068 NBQX (FG9202) HY-12758A YHO-13351
VDAC HY-15640 Capsazepine HY-15258 Lesinurad (RDEA594)
HY-15991 Tenapanor (AZD1722) HY-12882A Ifenprodil
HY-12428 A-1165442 HY-100208 HC-067047
HY-101507 Pico145 (HC-608) HY-14483 AF-353 (Ro-4)
HY-111925 BI-749327 HY-P0117 Tat-NR2B9c (NA-1)
HY-13519 TRAM-34 HY-10634 AMG 517
HY-16589 Oligomycin A (MCH 32) HY-13646 Encequidar (HM30181)
HY-N2332A Methyllycaconitine HY-111325 Synta66
HY-12883 PF 05089771 HY-B1140 Diazoxide (Sch-6783)
11
MCE
Master of Small Molecules
Cytoskeleton
Arp2/3 Complex Cat. No. Product Name Cat. No. Product Name
Dynamin HY-13442A Eribulin Mesylate HY-19792 Mertansine (DM1)
Gap Junction Protein HY-15575 VcMMAE HY-13441 (-)-Blebbistatin
Integrin HY-15162 Monomethyl auristatin E (MMAE) HY-10913A Danegaptide (GAP-134)
Kinesin HY-15584 Taltobulin (HTI-286; SPA-110) HY-16141 Cilengitide (EMD 121974)
Microtubule/Tubulin HY-10222 Ixabepilone (BMS 247550) HY-14951 Firategrast (SB 683699)
Mps1 HY-15578 McMMAF HY-18676 OSU-T315
Myosin HY-B0015 Paclitaxel (Taxol) HY-15102 MK-0429 (L-000845704)
PAK HY-106268A Larazotide HY-N0488 Vincristine (Leurocristine)
HY-15583 Auristatin F HY-50759 Ispinesib (SB-715992)
HY-15204 Tonabersat (SB-220453) HY-12454 DM4
HY-B0011 Docetaxel (RP-56976) HY-P0023 Cyclo(-RGDfK)
HY-15278 Epothilone D (KOS 862) HY-12793 KPT-9274
HY-15886 Mdivi-1 HY-P0122 iRGD peptide (c(CRGDKGPDC))
HY-17029 Epothilone B (Patupilone) HY-13007 PF-3758309
HY-112162 BOS-172722 HY-12858 Empesertib (BAY 1161909)
NF-?B
IKK Cat. No. Product Name Cat. No. Product Name
Keap1-Nrf2 HY-112433 NIK SMI1 HY-112675 4-Octyl Itaconate
MALT1 HY-12212 Omaveloxolone (RTA-408) HY-P0151 SN50
NF-?B HY-18950 GSK2795039 HY-16561 Resveratrol (SRT501)
Reactive Oxygen Species HY-100523 ML385 HY-13060 ACHP (IKK-2 Inhibitor VIII)
HY-15473 MLN120B HY-B0215 Acetylcysteine (NAC)
HY-12213 CDDO-EA (RTA 405) HY-111941 GSK8612
HY-19356 Rocaglamide (Roc-A) HY-12276 MALT1 inhibitor MI-2
HY-100116A Mitoquinone (MitoQ) HY-18935A CBL0137
HY-101140 KI696 HY-115466 MLT-748
HY-13324 Bardoxolone (RTA 402) HY-B1960 Canthaxanthin
HY-13755 Sulforaphane HY-N0005 Curcumin
HY-D0937 Methoxy-PMS HY-13019 BI605906
HY-13453 BAY 11-7082 (BAY 11-7821) HY-14645 (-)-DHMEQ
HY-15725 CDDO-Im (RTA-403; TP-235) HY-13982 JSH-23
HY-D0940 H2DCFDA HY-10514 BX795
12
www.MedChemExpress.com
Inhibitors • Agonists • Screening Libraries
TGF-beta/Smad
PKC Cat. No. Product Name Cat. No. Product Name
ROCK HY-10230 Midostaurin (PKC412) HY-13434 Ionomycin (SQ23377)
TGF-beta/Smad HY-13226 Galunisertib (LY2157299) HY-10343 Sotrastaurin (AEB071)
TGF-? Receptor HY-10431 SB-431542 HY-13012 RepSox (E-616452)
HY-10071 Y-27632 HY-103021 LY3200882
HY-15141 Staurosporine HY-N0439 Asiaticoside
HY-12043 SB 525334 HY-12953 R-268712
HY-15307 SLx-2119 (KD-025) HY-P0118 Disitertide (P144)
HY-15392 Chroman 1 HY-10195B Ruboxistaurin (LY 333531)
HY-12075 LY2109761 HY-15685 Ripasudil (K-115)
HY-13013 (E)-SIS3 HY-13689 Go 6983 (Gö 6983)
HY-B0673 Pirfenidone (AMR69) HY-12659 LX7101
HY-100347A SRI-011381 HY-13521 SB-505124
HY-19928 Vactosertib (TEW-7197) HY-13867 Bisindolylmaleimide I
HY-10432 A 83-01 HY-10342 Enzastaurin (LY317615)
HY-12071 LDN193189 (DM-3189) HY-112782 VTX-27
Vitamin D Related
Vitamin D Cat. No. Product Name
Vitamin D Receptor (VDR) HY-10002 Calcitriol (1,25-Dihydroxyvitamin D3)
HY-A0020 Eldecalcitol (ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3)
HY-32343 Secalciferol ((24R)-24,25-Dihydroxyvitamin D3)
HY-15830 25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol)
HY-10001 Calcipotriol (MC 903; Calcipotriene)
HY-50919 Paricalcitol
HY-76915 24, 25-Dihydroxy VD3
HY-77274 Calcitriol Impurities D
HY-15254 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3
HY-76801 24, 25-Dihydroxy VD2 (24,25-Dihydroxy vitamin D2)
HY-32350 Ercalcitriol (1?,25-Dihydroxy Vitamin D2)
HY-32342 Falecalcitriol
HY-15332 Alfacalcidol-D6
HY-32349 Ercalcidiol (25-hydroxy Vitamin D2)
HY-15157 Calcitetrol (1?, 24, 25-Trihydroxy VD3)
13
MCE
Master of Small Molecules
Antibody-drug Conjugate/ADC Related
The antibody-drug conjugate (ADC) is a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules
(payloads) through chemical linkers. ADCs increase the cell-killing potential of monoclonal antibodies (mAbs), and confer higher tumor selectivity.
Some ADCs has been approved by FDA.
ADC Cytotoxin
Destroys cancer cells
50+
ADC Cytotoxins
Cat. No. Product Name
HY-15162 Monomethyl auristatin E ADC Linker
Joins antibody and drug
HY-15162A D8-MMAE
HY-15584 Taltobulin
HY-15142 Doxorubicin Hydrochloride
HY-13316 Mitomycin C Antibody
Targets cancer cells
HY-19610 alpha-Amanitin
HY-B0015 Paclitaxel
HY-15583 Auristatin F Drug-Linker Conjugates for 500+
HY-16261 Aldoxorubicin ADC ADC Linkers
HY-19609 Calicheamicin Cat. No. Product Name Cat. No. Product Name
HY-19792 Mertansine HY-15575 VcMMAE HY-78738 MC-Val-Cit-PAB
HY-13631D Dxd HY-15578 McMMAF HY-12362 Val-cit-PAB-OH
HY-13062 Daunorubicin Hydrochloride HY-101070 SMCC-DM1 HY-41189 Fmoc-Val-Cit-PAB-PNP
HY-14519 Methotrexate HY-13631E Deruxtecan HY-20336 Mc-Val-Cit-PABC-PNP
HY-13704 SN-38 HY-100374 Val-Cit-PAB-MMAE HY-43869 Vipivotide tetraxetan Linker
HY-15579A MMAF Hydrochloride HY-111012 DBCO-(PEG)3-VC-PAB-MMAE HY-42973 DBCO-NHS ester
HY-16700 PNU-159682 HY-100566 SuO-Val-Cit-PAB-MMAE HY-114430 Fmoc-Phe-Lys(Boc)-PAB-PNP
HY-13061 Daun02 HY-117410 Vipivotide tetraxetan HY-100216 SPDP
HY-15579AS D8-MMAF Hydrochloride HY-126681 SC-VC-PAB-MMAE HY-19318 Fmoc-Val-Cit-PAB
HY-16560 Camptothecin
Entreprise(s) concernée(s) :
Produit(s) concerné(s) :
Date d'upload du document :
jeudi 23 mai 2024