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Flyer_Oligo_DrugDiscovery
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High Quality and Consistency
Providing comprehensive hands-on expertise in the synthesis of a broad range
of ASO chemistries, combined with highly optimized synthesis platforms. The
result is oligonucleotides of the highest quality.
Fast Turnaround Times
High scalability and adaptability of the production processes provide you with
fast turn-around times for your drug discovery process.
Attractive Prices
Tailor-made and highly automated manufacturing processes create ASOs,
siRNAs, and other oligonucleotides for potential therapeutic applications at
attractive prices.
Antisense Oligonucleotides
for Early Drug Discovery
Microsynth AG, SwitzerlandSch?tzenstrasse 15 ? P.O. Box ? CH - 9436 Balgach ? Phone + 41ff71ff722ff83 33 ? info @microsynth.ch ? www.microsynth.com
THE SWISS DNA COMPANYFlyer ? Oligonucleotide Synthesis
Overview
Several oligonucleotide-based drugs
have been approved by regulatory
agencies (e.g. FDA and EMEA) during
the past two decades. Antisense and
RNAi therapeutics - which are cur -
rently amongst the hottest topics in
the world of research and develop -
ment - are forms of treatments that are
clearly distinguished from traditional
approaches such as the small mole -
cule or antibody-based approaches.
Since they can be directed against
a broad variety of RNA targets (i.e.
premRNA, mRNA, lncRNA, miRNA),
they open the door to the treatment
of a wide range of diseases, including
those that are considered undrugga -
ble on the protein level.
Microsynth is a well known oligo sup -
plier with more than three decades of
experience. We have developed tech -
nical capabilities and expertise that
enable us to offer a portfolio of ther -
apeutic oligonucleotides, which are
especially suited for leveraging your
early drug discovery program in this
field.
Microsynth Core Competency Areas to Support Your Drug Discovery Program
Figure 1. Steps of a typical process for the discovery
of therapeutic oligos, where Microsynth can support
you. A list confirming the typical services provided
by Microsynth gives you an insight into our exten -
sive service portfolio.
Product Specifications and Services
Backbones and Modifications
DNA, RNA, 2’ MOE, 2’ OMe, LNA, PTO,
2’F, GalNAc, S-cEt 1
Purification
• RP HPLC (single and dual)
• IP RP HPLC
• IEX HPLC
• Dialysis
Quality Control and Documentation
• Online Trityl monitoring
• MALDI-TOF
• Analytical HPLC
• Various Certificates of Analysis
Available Products
• Antisense oligonucleotides (ASO)
• siRNA
• Anti-microRNA (AMO)
• Aptamers
• CpG oligonucleotides
Getting Started with Microsynth
Our modular integrated synthe -
sis process gives us the flexibility to
accommodate your project at any
stage of your discovery program.
Please contact one of our project man -
agers to discuss your personal program
and needs. Our dedicated experts will
then create a customized project pro -
posal and timing schedule for you that
we are confident will meet your expec -
tations.
1) On request
- High-throughput synthesis of screening oligos
- Broad range of synthesis chemistries and modifcations
- Flexible and fast production times
- Batch sizes up to 200 oligos - larger sizes are possible if you wish to
discuss this option
Drug Discovery
and Screening Lead Optimization
- Highly modifed oligos (multiple
diferent modifcations are possible)
- Manufacturing from nmol to mg quantities
- Broad spectrum of post-synthetic conjugation techniques (e.g. termi-
nal GalNAc conjugates)
- Customized processes
Microsynth AG, SwitzerlandSch?tzenstrasse 15 ? P.O. Box ? CH - 9436 Balgach ? Phone + 41ff71ff722ff83 33 ? info @microsynth.ch ? www.microsynth.com
THE SWISS DNA COMPANYFlyer ? Oligonucleotide Synthesis
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Date d'upload du document :
lundi 27 juin 2022